Antidepressant-like effect of different estrogenic compounds in the forced swimming test
Antidepressant-like effect of different estrogenic compounds in the forced swimming test
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DOI：
10.1038/sj.npp.1300097
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发表时间：
2003-05-01
影响因子：
7.6
通讯作者：
López-Rubalcava, C
中科院分区：
文献类型：
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作者：
Estrada-Camarena, E;Fernández-Guasti, A;López-Rubalcava, C
本研究采用强迫游泳试验（FST）评价了天然雌激素17 β-雌二醇（E2，2.5-10 μ g/大鼠）、合成甾体雌激素乙炔基-雌二醇（EE 2，1.25-10.0 μ g/大鼠）和非甾体合成雌激素二乙基-雌酚（DES，0.25-1.0 mg/大鼠）在切除卵巢的成年雌性Wistar大鼠中可能的抗抑郁样作用。将雌激素诱导的行为特征与抗抑郁药氟西汀（FLX，2.5-10 mg/kg）和地昔帕明（DEXPA，2.5-10 mg/kg）诱导的行为特征进行比较。此外，分析了雌激素化合物的抗抑郁样作用的时间过程。FLX和ESTA诱导的抗抑郁症样作用，其特征在于减少不动性和增加游泳FLX和减少不动性和增加攀爬ESTA。E2和EE 2都产生了减少不动性和增加游泳，这表明抗抑郁剂样的行动。DES在任何测试剂量下都不影响这种抑郁症动物模型的反应。E2（10 μ g/大鼠）和EE 2（5 μ g/大鼠）作用的时程分析表明，两种化合物在注射后1小时观察到抗抑郁样作用，持续2-3天。
The present study evaluated the possible antidepressant-like action of the natural estrogen 17beta-estradiol (E2, 2.5-10 mug/rat), the synthetic steroidal estrogen ethinyl-estr-adiol (EE2, 1.25-10.0 mug/rat), and the nonsteroidal synthetic estrogen, diethyl-stillbestrol (DES, 0.25-1.0 mg/ rat) in ovariectomized adult female Wistar rats using the forced swimming test (FST). The behavioral profile induced by the estrogens was compared with that induced by the antidepressants fluoxetine (FLX, 2.5-10 mg/kg) and desipramine (DMI, 2.5-10 mg/kg). In addition, the temporal course of the antidepressant-like action of the estrogenic compounds was analyzed. FLX and DMI induced an antidepressant-like effect characterized by a reduced immobility and increased swimming for FLX and decreased immobility and increased climbing for DMI. Both E2 and EE2 produced a decrease in immobility and an increase in swimming, suggesting an antidepressant-like action. DES did not affect the responses in this animal model of depression at any dose tested. The time course analysis of the actions of E2 (10 mug/rat) and EE2 (5 mug/rat) showed that both compounds induced an antidepressant-like effect observed I h after their injection lasting for 2-3 days.