It takes two transposons to tango - transposable-element-mediated chromosomal rearrangements
It takes two transposons to tango - transposable-element-mediated chromosomal rearrangements
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DOI：
10.1016/s0168-9525(00)02104-1
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发表时间：
2000-10-01
影响因子：
11.4
通讯作者：
Gray, YHM
中科院分区：
文献类型：
--
作者：
Gray, YHM
转座因子（te）比其他细胞过程更有效、更特异地促进各种染色体重排（1-3）。对这些事件的一种解释是基因组中存在的TE的多个拷贝之间的同源重组。虽然这种情况确实会发生，但来自细菌、植物和动物的许多TE系统的有力证据表明，另一种机制-替代转位-诱导了很大比例的TE相关染色体重排。本文回顾了一些不相关但结构相似的te的替代转位的证据。交替转位和V(D)J重组之间的相似之处也进行了讨论，因为交替转位作为一种遗传工具的使用。
Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes(1-3). One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool.