Fibroblasts in fibrosis: novel roles and mediators.
Fibroblasts in fibrosis: novel roles and mediators.
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DOI：
10.3389/fphar.2014.00123
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发表时间：
2014
影响因子：
5.6
通讯作者：
Feghali-Bostwick CA
中科院分区：
文献类型：
--
作者：
Kendall RT;Feghali-Bostwick CA
成纤维细胞是全身结缔组织中最常见的细胞类型，也是这些组织广泛细胞外基质(ECM)的主要来源。它们也是细胞外基质病理性纤维化堆积的中心介质，以及因长期组织损伤和慢性炎症而发生的细胞增殖和分化。成纤维细胞系的转化涉及经典的发育信号程序，并包括令人惊讶的多样化的前体细胞类型--最明显的是作为纤维化表型的顶端的肌成纤维细胞。肌成纤维细胞表现出过度的细胞外基质产生；结构性分泌，对细胞因子、趋化因子和生长因子等化学信号高度敏感；并被赋予收缩装置，使它们能够物理地操纵细胞外基质纤维以闭合开放的伤口。除了细胞外基质的产生，成纤维细胞还有多种伴随的生物学作用，如伤口愈合、炎症和血管生成，这些都与纤维化的过程交织在一起。我们现在认识到许多常见的成纤维细胞相关的特征，跨越各种生理和病理延长的过程。事实上，对于非癌性成纤维细胞与肿瘤的相互作用在癌症进展中的作用已经出现了新的认识。尽管目前主要的纤维化临床治疗涉及非特异性免疫抑制和抗增殖药物，但正在研究的各种潜在治疗方法专门针对成纤维细胞生物学。
Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM) characteristic of these tissues. They are also the central mediators of the pathological fibrotic accumulation of ECM and the cellular proliferation and differentiation that occurs in response to prolonged tissue injury and chronic inflammation. The transformation of the fibroblast cell lineage involves classical developmental signaling programs and includes a surprisingly diverse range of precursor cell types—most notably, myofibroblasts that are the apex of the fibrotic phenotype. Myofibroblasts display exaggerated ECM production; constitutively secrete and are hypersensitive to chemical signals such as cytokines, chemokines, and growth factors; and are endowed with a contractile apparatus allowing them to manipulate the ECM fibers physically to close open wounds. In addition to ECM production, fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. We now recognize many common fibroblast-related features across various physiological and pathological protracted processes. Indeed, a new appreciation has emerged for the role of non-cancerous fibroblast interactions with tumors in cancer progression. Although the predominant current clinical treatments of fibrosis involve non-specific immunosuppressive and anti-proliferative drugs, a variety of potential therapies under investigation specifically target fibroblast biology.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
Somanath, Payaningal R.
DOI：
10.1164/rccm.200405-612oc
发表时间：
2005-04-15
影响因子：
24.7
作者：
Bonniaud, P;Margetts, PJ;Gauldie, J
通讯作者：
Gauldie, J