Alterations in sleep physiology in young children with insulin-dependent diabetes mellitus: Relationship to nocturnal hypoglycemia
Alterations in sleep physiology in young children with insulin-dependent diabetes mellitus: Relationship to nocturnal hypoglycemia
复制标题
DOI：
10.1067/mpd.2000.107186
复制
发表时间：
2000-08-01
影响因子：
5.1
通讯作者：
Stores, G
中科院分区：
文献类型：
--
作者：
Matyka, KA;Crawford, C;Stores, G
目的：探讨糖尿病本身及夜间低血糖对胰岛素依赖型糖尿病（IDDM）患儿睡眠的影响。设计：对29名IDDM儿童进行了3次夜间多导睡眠图检查，其中两次是在代谢分析期间进行的。对14名儿童（中位数[范围]8.7[5.9 ~ 12.9]岁）的睡眠数据进行分析，其中一晚低血糖，另一晚非低血糖。对照组的7名儿童（9[5.6至11.4]岁）接受了2晚的多导睡眠图检查，一次是在代谢分析期间（评估代谢分析的影响），对照组的15名儿童只接受了多导睡眠图检查（评估糖尿病本身的影响并与指数组进行比较）。结果：与对照组相比，IDDM患儿睡眠中断（短醒，睡眠时间百分比，0.8 [0.5 ~ 1.9]vs 0.0[0.0 ~ 0.3]，中位数[四分位数间距]，IDDM与对照组分别，P = 0.001；长醒，1.2 [0.7 ~ 3.0]vs 0.0 [0.0 ~ 0.0], P = 0.033；醒总次数，6 [3.5 ~ 11.5]vs 1 [0 ~ 2], P = 0.002）。血液采样干扰睡眠，长时间醒来占睡眠时间的百分比增加（0.3[0.0至3.8]vs 4.3[3.1至16.9]，非采样与采样夜分别，P = 0.003）。低血糖发作很严重，血糖最低点为2.0[1.4至3.3]mmol/L(35.0[24.5至57.8]mg/dL)，持续时间为308[30至630]分钟，对睡眠没有影响。结论：与对照组相比，糖尿病患儿有睡眠中断，但夜间深度低血糖对睡眠质量没有影响。
Objectives: To examine the effect of diabetes per se and nocturnal hypoglycemia on sleep in children with insulin-dependent diabetes mellitus (IDDM).Design: Overnight polysomnography was performed on 3 occasions in 29 children with IDDM - twice during metabolic profiling. Sleep data were analyzed from 14 children (median [range], 8.7 [5.9 to 12.9] years) with a night of hypoglycemia and a nonhypoglycemic night. Seven children in the control group (9 [5.6 to 11.4] years) underwent 2 nights of polysomnography, once during metabolic profiling (to assess the effects of metabolic profiling) and 15 members of the control group had polysomnography only (to assess the effects of diabetes per se and to compare with the index group).Results: Children with IDDM had disrupted sleep compared with the control group (short wakes, percentage of sleep time, 0.8 [0.5 to 1.9] vs 0.0 [0.0 to 0.3], median [interquartile range], IDDM vs control group, respectively, P = .001; long wakes, 1.2 [0.7 to 3.0] vs 0.0 [0.0 to 0.0], P = .033; total number of wakes, 6 [3.5 to 11.5] vs 1 [0 to 2], P = .002). Blood sampling disrupted sleep with increased long wakes as percentage of sleep time (0.3 [0.0 to 3.8] vs 4.3 [3.1 to 16.9], nonsampling vs sampling night, respectively, P = .003). Episodes of hypoglycemia were profound, with a glucose nadir of 2.0 [1.4 to 3.3] mmol/L, (35.0 [24.5 to 57.8] mg/dL) and prolonged, 308 [30 to 630] minutes, with no effect on sleep.Conclusions: Children with diabetes had disrupted sleep compared with a control group, but there was no effect of profound nocturnal hypoglycemia on sleep quality.