Confluenine G, a new compound from a basidiomycetous yeast Moesziomyces sp. FKI-9540 derived the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae).
Confluenine G, a new compound from a basidiomycetous yeast Moesziomyces sp. FKI-9540 derived the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae).
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Confluenine G，一种来自担子菌酵母 Moesziomyces sp 的新化合物。
DOI：
10.1093/bbb/zbac062
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Yukihiro Asami
中科院分区：
文献类型：
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作者：
N. Kondo;Kazunari Sakai;Aoi Kimishima;Rei Hokari;Masako Honsho;Mai Sato;K. Naher;H. Yuge;M. Iwatsuki;K. Nonaka;Yukihiro Asami
大多数来源于微生物的天然产物是从放线菌和丝状真菌中寻找的。作为在天然产物的探索性研究中开发新的微生物资源的尝试，我们从假定具有生物合成基因簇的未开发的微生物类群中寻找新的化合物。从一种产自粘虫Acherontia lachesis（鳞翅目，天蛾科）肠道的担子菌Moesziomyces sp. FKI-9540发酵液中分离得到一个新化合物confluenine G（1）和一个已知化合物（2 Z）-2-辛基-2-戊烯二酸（2）。根据高分辨电喷雾质谱和核磁共振谱的分析结果，确定了化合物1的平面结构。Confluenine G（1）是一种新的氮氧化异亮氨酸类似物，分子中含有稀有的肟和异羟肟酸亚结构。
Most natural products derived from microorganisms have been sought from actinomycetes and filamentous fungi. As an attempt to develop new microbial resources in the exploratory research for natural products, we searched for new compounds from unexploited microbial taxa presumed to have biosynthetic gene clusters. A new compound confluenine G (1) and a known compound (2Z)-2-octyl-2-pentenedioic acid (2) were isolated from a cultured broth of basidiomycetous yeast, Moesziomyces sp. FKI-9540, derived from the gut of a moth Acherontia lachesis (Lepidoptera, Sphingidae). Based on the results of HR-ESI-MS and NMR analyses, the planar structure of 1 was elucidated. Confluenine G (1) was a new analog of nitrogen-oxidized isoleucine and had rare substructures with oxime and hydroxamic acid in molecule.