Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral grafts
Treatment of focal articular cartilage lesions of the knee with autogenous osteochondral grafts
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自体骨软骨移植治疗膝关节局灶性关节软骨病变
DOI：
10.1007/s004020100343
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发表时间：
2002
影响因子：
2.3
通讯作者：
Ching‐Jen Wang
中科院分区：
文献类型：
--
作者：
Ching‐Jen Wang
对15例患者（16个膝关节）进行了一项回顾性研究，这些患者接受了自体骨软骨移植治疗膝关节局灶性全层关节软骨缺损，随访2- 4年，显示80%的临床结果良好或极佳。临床结果与基础诊断（包括骨坏死、骨软骨炎和创伤性软骨缺损）或病变尺寸小于600 mm 2无相关性。然而，大于600 mm 2的软骨病变与纤维组织形成增加和移植物与宿主组织之间的裂隙以及不良结果相关。症状的改善呈时间依赖性，范围为6至16周，表明移植物的术后保护是必要的。中期随访时，膝关节退行性病变的影像学进展未见。因此，自体骨软骨移植物被认为是治疗膝关节中度关节软骨缺损的良好方法。
A retrospective study of 15 patients with 16 knees who underwent osteochondral autografts for focal full thickness articular cartilage defects of the knee with 2- to 4-year follow-up showed 80% good or excellent clinical results. There was no correlation of the clinical results with the underlying diagnoses, including osteonecrosis, osteochondritis dessicans and traumatic cartilage defect, or a size of the lesion smaller than 600 mm2. However, cartilage lesions larger than 600 mm2were associated with increasing fibrous tissue formation and fissuring between the grafts and the host tissues and poor results. The improvement in symptoms appeared time-dependent, ranging from 6 to 16 weeks, suggesting that postoperative protection of the graft is warranted. There was no radiographic progression of degenerative changes of the knee on the medium-term follow-up. Therefore, an autogenous osteochondral graft is considered a good method in the treatment of knees with moderately sized articular cartilage defects.