Acute Kidney Injury: Global Health Alert
Acute Kidney Injury: Global Health Alert
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DOI：
10.1097/tp.0b013e31828848bc
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发表时间：
2013-03-15
期刊：
影响因子：
6.2
通讯作者：
Mehta, Ravindra L.
中科院分区：
文献类型：
--
作者：
Li, Philip Kam Tao;Burdmann, Emmanuel A.;Mehta, Ravindra L.
急性肾损伤（AKI）在发展中国家和发达国家越来越普遍，并与严重的发病率和死亡率相关。大多数 AKI 病因可以通过个人、社区、区域和院内层面的干预措施来预防。有效的措施必须包括全社区的努力，以提高对 AKI 破坏性影响的认识，并提供预防策略以及早期识别和管理的指导。应集中精力尽量减少 AKI 的病因，提高对高危患者连续测量血清肌酐重要性的认识，并记录急症患者的尿量以实现早期诊断；替代生物标志物尚无明确的作用。需要制定方案来系统地管理肾前性疾病和特定感染。有关 AKI 真实发病率和临床影响的更准确数据将有助于提高该疾病在社区中的重要性，并提高政府、公众、全科医生和家庭医生以及其他医疗保健专业人员对 AKI 的认识，以帮助预防该疾病。预防是避免 AKI 相关死亡和发病沉重负担的关键。
Acute kidney injury (AKI) is increasingly prevalent in developing and developed countries and is associated with severe morbidity and mortality. Most etiologies of AKI can be prevented by interventions at the individual, community, regional, and in-hospital levels. Effective measures must include community-wide efforts to increase an awareness of the devastating effects of AKI and provide guidance on preventive strategies, and early recognition and management. Efforts should be focused on minimizing the causes of AKI, increasing awareness of the importance of serial measurements of serum creatinine in high-risk patients, and documenting urine volume in acutely ill people to achieve early diagnosis; there is as yet no definitive role for alternative biomarkers. Protocols need to be developed to systematically manage prerenal conditions and specific infections. More accurate data about the true incidence and clinical impact of AKI will help raise the importance of the disease in the community and increase awareness of AKI by governments, the public, and general and family physicians and other health care professionals to help prevent the disease. Prevention is the key to avoid the heavy burden of mortality and morbidity associated with AKI.