Association of nNOS gene polymorphism with ischemic stroke in Han Chinese of North China.
Association of nNOS gene polymorphism with ischemic stroke in Han Chinese of North China.
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DOI：
10.1155/2013/891581
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发表时间：
2013
影响因子：
--
通讯作者：
Ma S
中科院分区：
文献类型：
--
作者：
Dai Y;He Z;Sui R;Jiang Z;Ma S
一氧化氮（NO）是重要的信使分子和效应分子。本研究旨在探讨华北汉族神经元一氧化氮合酶（nNOS）基因多态性与缺血性脑卒中的关系。这是一项病例对照研究。总共招募了 413 名华北汉族缺血性脑卒中患者。其中男性201人，女性212人。此外，还有 477 名健康受试者作为对照，其中男性 224 名，女性 253 名。采用多重 SNaPshot 检测 nNOS 基因多态性（rs2293050、rs2139733、rs7308402 和 rs1483757）。结果显示，患者和对照组之间的 rs1483757、rs2139733 和 rs2293050 基因型和等位基因频率具有可比性。然而，与对照组相比，缺血性中风患者的 AG 基因型和 A 等位基因频率显着降低（P = 0.037，P = 0.041）。调整混杂因素（性别、年龄、吸烟、饮酒史、高血压和糖尿病）后，AG基因型和A等位基因仍与缺血性卒中相关（OR = 0.572，95% CI：0.335–0.978，P = 0.041；OR = 0.611，95% C：0.378–0.985，P = 0.041），两者均被发现是保护因素。我们的研究结果表明nNOS rs7308402基因多态性与华北汉族缺血性脑卒中相关。
Nitric oxide (NO) is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS) gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757). Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P = 0.037, P = 0.041). After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes), AG genotype and A allele were still related to ischemic stroke (OR = 0.572, 95% CI: 0.335–0.978, P = 0.041; OR = 0.611, 95% C: 0.378–0.985, and P = 0.041) and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.
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影响因子：
37.8
作者：
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DOI：
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