Sympathetic Response and Outcomes Following Renal Denervation in Patients With Chronic Heart Failure: 12-Month Outcomes From the Symplicity HF Feasibility Study
Sympathetic Response and Outcomes Following Renal Denervation in Patients With Chronic Heart Failure: 12-Month Outcomes From the Symplicity HF Feasibility Study
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DOI：
10.1016/j.cardfail.2017.06.004
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发表时间：
2017-09-01
影响因子：
6
通讯作者：
Krum, Henry
中科院分区：
文献类型：
--
作者：
Hopper, Ingrid;Gronda, Edoardo;Krum, Henry
背景：心力衰竭（HF）与慢性交感神经激活有关。肾去神经术（RDN）旨在通过消融肾交感神经来减少交感神经活动。我们在一项前瞻性、多中心、单臂可行性研究中调查了 RDN 对慢性心力衰竭并并发肾功能不全的患者的影响。方法和结果：39 名慢性收缩性心力衰竭患者（左心室射血分数 [LVEF]）
Background: Heart failure (HF) is associated with chronic sympathetic activation. Renal denervation (RDN) aims to reduce sympathetic activity by ablating the renal sympathetic nerves. We investigated the effect of RDN in patients with chronic HF and concurrent renal dysfunction in a prospective, multicenter, single-arm feasibility study.Methods and Results: Thirty-nine patients with chronic systolic HF (left ventricular ejection fraction [LVEF]