Carcinoma of prostate: response of plasma luteinizing hormone and testosterone to oestrogen therapy.
Carcinoma of prostate: response of plasma luteinizing hormone and testosterone to oestrogen therapy.
复制标题
前列腺癌：血浆黄体生成素和睾酮对雌激素治疗的反应。
作者：
A. Alder;H. Burger;J. Davis;A. Dulmanis;B. Hudson;G. Sarfaty;W. Straffon
在Huggins及其同事的开创性研究之后，雌激素疗法已成为治疗局部和转移性前列腺癌的一种方法（1939，1940，1941）。在绝大多数受影响的患者中，前列腺肿瘤及其转移是前列腺敏感的，并且内分泌治疗已经进行，目的是改变激素环境，特别是降低雄激素水平。睾丸切除术和/或给予雌激素已成为治疗的基础，但对它们对垂体促性腺激素和睾酮（男性主要生理活性雄激素）分泌的影响知之甚少。此外，垂体切除术治疗前列腺癌的结果，特别是在雌激素和睾丸切除术后复发的患者中，已经足够令人鼓舞，值得进一步探索这一程序，特别是在疾病的早期阶段。进行了以下研究，首先是为了获得关于雌激素治疗对前列腺癌患者睾酮和促黄体生成素水平的影响的信息，其次是为了提供比较这种治疗与作为转移性疾病初始程序的垂体切除术的效果的基础。
Oestrogen therapy has become well established as a method of treatment of local and metastatic prostatic carcinoma, following the pioneering investigations ot Huggins and his co-workers (1939, 1940, 1941). In a large majority of affected patients prostatic tumours and their metastases are hormone-sensitive and endocrine therapy has been undertaken with the purpose of altering the hormonal milieu and, specifically, of lowering androgen levels. Orchidectomy and/or the administration of oestrogens have become cornerstones of treatment, but relatively little is known of their effects on the secretion of pituitary gonadotrophins and of testosterone, the major physiologically active androgen in man. Furthermore, the results of hypophysectomy for prostate cancer, especially in patients who have relapsed after oestrogen and orchidectomy, have been encouraging enough to warrant further exploration of this procedure, particularly at an earlier stage of the disease. The following studies were undertaken, firstly to gain information about the effects of oestrogen treatment specifically on testosterone and luteinizing hormone levels in patients with prostatic cancer, and, secondly, to provide a basis for comparison of the effects of this treatment with those of hypophysectomy done as the initial procedure for metastatic disease.