Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice
Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice
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芒果苷调节脂多糖诱导的小鼠认知缺陷和血红素加氧酶-1
DOI：
10.1016/j.intimp.2015.10.035
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发表时间：
2015-12-01
影响因子：
5.6
通讯作者：
Song, Yuanjian
中科院分区：
文献类型：
--
作者：
Fu, Yanyan;Liu, Hongzhi;Song, Yuanjian
越来越多的证据表明，脂多糖（ITS）可以诱导神经炎症，最终导致认知功能障碍。芒果苷是一种天然的葡萄糖氧杂蒽酮，具有多种生物活性。本研究旨在观察芒果苷对脂多糖（LPS）所致认知功能障碍的影响并探讨其作用机制。通过腹腔内注射LPS（lmg/kg）连续5天诱导小鼠脑损伤。芒果苷经口预处理（50 mg/kg）7天，然后在LPS注射后处理（50 mg/kg）5天。Morris水迷宫检测认知功能的变化。采用免疫组化和免疫印迹法检测海马组织中白细胞介素-6（IL-6）和血红素氧合酶-1（HO-1）的表达。结果表明芒果苷能改善认知功能障碍。此外，芒果苷减少LPS诱导的海马IL-6的产生，并增加HO-1。总之，这些结果表明芒果苷减弱LPS诱导的认知缺陷，这可能与海马中HO-1的调节有关。(C)2015年由Elsevier B. V.出版
Accumulating evidence reveals that lipopolysaccharide (ITS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1 mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50 mg/kg) for seven days and then treatmented (50 mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus. (C) 2015 Published by Elsevier B.V.