Water-soluble diiron hexacarbonyl complex as a CO-RM: controllable CO-releasing, releasing mechanism and biocompatibility
Water-soluble diiron hexacarbonyl complex as a CO-RM: controllable CO-releasing, releasing mechanism and biocompatibility
复制标题
水溶性六羰基二铁配合物作为CO-RM：可控CO释放、释放机制和生物相容性
DOI：
10.1039/c3dt51281a
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Liu, Xiaoming
中科院分区：
文献类型：
--
作者：
Long, Li;Jiang, Xiujuan;Liu, Xiaoming
在四氢呋喃(THF)中，将硫甘醇与Fe-3(CO)(12)反应，合成了水溶性二铁六甲酰配合物[Fe-2{MU-SCH_2CH(OH)CH2(OH)}(2)(CO)(6)](1)。该二铁络合物被用作一氧化碳释放分子(CO-RM)。CO的释放是通过半胱胺(临床药物半胱胺)取代结合的CO而启动的。取代产物的进一步分解至少部分地通过氧化过程形成了单铁(II)二羰基物种，同时在惰性气氛下释放了更多的CO。对CO释放过程中产生的三种中间体进行了光谱鉴定。络合物1的分解动力学对络合物和环孢素A均为一级反应。在开放的大气中，由于氧参与了络合物1的分解，CO的释放机制发生了变化。该体系对两个任意选择的细胞株QSG7701和HepG2显示出最低的细胞毒性，其IC_(50)为100mU·mol·L~(-1)。
A water soluble diiron hexacarbonyl complex, [Fe-2{mu-SCH2CH(OH)CH2(OH)}(2)(CO)(6)] (1), was synthesised by reacting thioglycol with Fe-3(CO)(12) in THF. This diiron complex was employed as carbon monoxide releasing molecule (CO-RM). The CO-releasing was initiated via substitution of the bound CO by cysteamine (CysA, a clinic medicine). Further decomposition of the substituted products led to at least partially the formation of monoiron(II) dicarbonyl species via oxidative process while releasing more CO under inert atmosphere. Three intermediates generated in the CO-releasing process were spectroscopically identified. The kinetics of the decomposition of complex 1 was first-order process for both the complex and CysA, respectively. Under open atmosphere, the CO-releasing mechanism altered due to the involvement of oxygen in the decomposition of complex 1. The system showed minimal cytotoxicity in two selected arbitrarily cell lines, QSG-7701 and HepG2, with IC50 at the scale of 100 mu mol L-1.