Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity.
Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity.
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DOI：
10.1039/d1cc01405f
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发表时间：
2021-05
影响因子：
4.9
通讯作者：
Akinobu Z. Suzuki;Taichi Sakano;Hirona Sasaki;Rei Watahiki;Masaki Sone;K. Horikawa;T. Furuta
中科院分区：
文献类型：
--
作者：
Akinobu Z. Suzuki;Taichi Sakano;Hirona Sasaki;Rei Watahiki;Masaki Sone;K. Horikawa;T. Furuta
我们设计了一个新的笼组，可以被光激活，只有在非内源性酶的存在下，当暴露于405 nm的光。由于细胞或组织可以通过外源表达的酶进行遗传标记，因此这种新方法可以作为一种策略，用于为光笼化合物增加靶向能力。
We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.