HIGH-DOSE CARBON-DIOXIDE CHALLENGE TEST IN ANXIETY DISORDER PATIENTS
HIGH-DOSE CARBON-DIOXIDE CHALLENGE TEST IN ANXIETY DISORDER PATIENTS
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DOI：
10.1016/0006-3223(90)90510-9
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发表时间：
1990-11-01
影响因子：
10.6
通讯作者：
JORDAN, F
中科院分区：
文献类型：
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作者：
GORMAN, JM;PAPP, LA;JORDAN, F
许多研究人员已经证明，恐慌症患者和可能的社交恐惧症患者对吸入二氧化碳(CO2)的焦虑效应高度敏感。在这项研究中，我们对惊恐障碍患者、社交恐惧症患者和正常对照组进行了35%二氧化碳和65%氧气(O2)的双呼吸吸入。基线时，惊恐障碍患者的特征是脉搏较高，焦虑评分较高，并有过度换气的证据。恐慌症患者和社交恐惧症患者对35%二氧化碳的惊慌率高于对室内空气的恐慌；正常对照组对二氧化碳的恐慌率并不高于对室内空气的恐慌。然而，与室内空气呼吸相比，我们没有发现呼吸二氧化碳时的焦虑水平、生理指标或生化指标存在显著差异。这些结果证实了早先关于惊恐障碍患者基线过度换气的报道。然而，与正常人相比，35%二氧化碳的剂量可能太高了，无法区分患者的呼吸反应。
Many investigators have shown that panic disorder patients and possibly social phobics are hypersensitive to the anxiogenic effects of inhaled carbon dioxide (CO2). In this study we administered double-breath inhalation of 35% CO2 and 65% oxygen (O2) to panic disorder patients, social phobics, and normal controls. At baseline, panic disorder patients were characterized by higher pulse, anxiety score, and evidence of hyperventilation. Panic patients and social phobics panicked more often to 35% CO2 than to room air; normal controls did not have a higher rate of panic to CO2 than to room air. However, we did not find significant group differences in anxiety level, physiological measures, or biochemical measures in response to CO2 breathing compared with room air breathing. These results confirm earlier reports of baseline hyperventilation in panic disorder patients. However, 35% CO2 may be too high a dose to differentiate respiratory responses of patients compared with normals.