The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation
The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation
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DOI：
10.1016/j.ypmed.2011.12.028
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发表时间：
2012-05-01
影响因子：
5.1
通讯作者：
Beelman, Robert B.
中科院分区：
文献类型：
--
作者：
Weigand-Heller, AuBrei J.;Kris-Etherton, Penny M.;Beelman, Robert B.
背景。麦角硫因 (ET) 是一种含硫氨基酸，具有抗氧化剂的作用。蘑菇是 ET 的主要来源，含量为 0.4 至 2.0 mg/g（干重）。蘑菇中的 ET 在人体中的生物利用度仍不清楚。目的。我们在一项试点研究中评估了 ET 在健康男性 (n = 10) 中的生物利用度，该研究采用随机、交叉、剂量反应、餐后时间进程设计，该方法于 2009 年在宾夕法尼亚州立大学普通临床研究中心进行。 ET 通过含有 8 g 和 16 g 蘑菇粉的蘑菇测试餐施用。测量餐后红细胞 ET 浓度。还监测了血浆葡萄糖、甘油三酯、HDL、LDL 和总胆固醇。使用 C 反应蛋白和 ORAC（总）评估炎症和氧化应激的生物标志物。结果。食用蘑菇后 ET 具有生物利用度，餐后甘油三酯反应的趋势表明，与 0 g 剂量相比，8 g 和 16 g ET 剂量后存在减弱作用。尽管 ET 具有抗氧化特性，但食用 8 克和 16 克蘑菇粉后 ORAC（总）值有所下降。结论。根据餐后红细胞摄取评估，双孢蘑菇中的麦角硫因具有生物利用度，并且摄入量与餐后 TG 反应减弱有关。 (C) 2012 Elsevier Inc. 保留所有权利。
Background. Ergothioneine (ET) is a sulfur containing amino acid that functions as an antioxidant. Mushrooms are a primary source of ET containing from 0.4 to 2.0 mg/g (dry-weight). The bioavailability of ET from mushrooms in humans remains unclear.Objective. We evaluated the bioavailability of ET in healthy men (n = 10) in a pilot study, using a randomized, cross-over, dose-response, postprandial time-course design, conducted at the General Clinical Research Center at Pennsylvania State University in 2009.Method. ET was administered through a mushroom test meal containing 8 g and 16 g of mushroom powder. Postprandial red blood cell concentrations of ET were measured. Plasma glucose, triglycerides, HDL, LDL and total cholesterol also were monitored. Biomarkers of inflammation and oxidative stress were evaluated using C-reactive protein and ORAC(total).Results. ET was bioavailable after consuming mushrooms and a trend in the postprandial triglyceride response indicated that there was a blunting effect after both the 8 g and 16 g ET doses were compared with the 0 g dose. Despite ET's antioxidant properties, ORAC(total) values decreased after the 8 g and 16 g mushroom meal.Conclusions. Ergothioneine from A. bisporus mushrooms is bioavailable as assessed by red blood cell uptake postprandially, and consumption is associated with an attenuated postprandial TG response. (C) 2012 Elsevier Inc. All rights reserved.