The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology
The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology
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DOI：
10.1007/s10439-007-9423-6
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发表时间：
2008-02-01
影响因子：
3.8
通讯作者：
Decuzzi, Paolo
中科院分区：
文献类型：
--
作者：
Gentile, Francesco;Ferrari, Mauro;Decuzzi, Paolo
纳米颗粒在血管中的纵向运输已经用描述为卡森流体的血液进行了分析。从Taylor和阿里斯理论出发，导出了有效纵向扩散（D-eff）的显式表达式，该表达式非线性地依赖于流变参数xi（c），即塞与容器半径之比; xi（c）或Pi的增加具有降低D-eff的效果，因此血液的流变性和血管的渗透性都可以构成纳米颗粒血管内递送的生理屏障。
The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (D-eff) depending non-linearly on the rheological parameter xi(c), the ratio between the plug and the vessel radii; and on the permeability parameters Pi and Omega; related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of xi(c) or Pi has the effect of reducing D-eff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.