'Magnetic bandages' for targeted delivery of therapeutic agents
'Magnetic bandages' for targeted delivery of therapeutic agents
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DOI：
10.1088/0953-8984/18/38/s23
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发表时间：
2006-09-27
影响因子：
2.7
通讯作者：
Haefeli, U. O.
中科院分区：
文献类型：
--
作者：
Hayden, M. E.;Haefeli, U. O.
我们研究平面周期性磁化结构用于靶向或控制治疗剂的递送连接到小的磁性颗粒，并推导出简单的相关静磁力的解析表达式。我们表明，改善粒子捕获或限制特性是可能的，相对于那些可以获得更传统的（即。e.均匀磁化的）结构。这些改进包括在近距离处更大的力（对于等效磁化密度），以及在平行于磁体表面的任意大区域上都是单向和均匀的力。在附录中总结了垂直于其轴均匀磁化的长棒（具有圆形和椭圆形横截面）附近的点状磁性粒子所受静磁力的表达式。
We investigate planar periodically magnetized structures for use in targeting or controlling the delivery of therapeutic agents attached to small magnetic particles, and derive simple analytic expressions for the relevant magnetostatic forces. We show that improved particle trapping or confinement characteristics are possible relative to those that can be obtained with more conventional ( i. e. uniformly magnetized) structures. These improvements include forces that are larger at close range ( for equivalent magnetization densities) and that are both unidirectional and uniform over arbitrarily large areas parallel to the magnet surface. Expressions for the magnetostatic forces exerted on point- like magnetic particles in the vicinity of long rods ( with circular and ellipsoidal cross sections) uniformly magnetized perpendicular to their axes are summarized in an appendix.