Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification
Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification
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DOI：
10.1152/jn.00034.2019
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发表时间：
2021-02-01
影响因子：
2.5
通讯作者：
Kao, M. H.
中科院分区：
文献类型：
--
作者：
Palmer, S. E.;Wright, B. D.;Kao, M. H.
练习复杂的运动手势需要进行运动探索，以达到与目标更好的匹配，但人们对这种探索的神经编码知之甚少。我们研究了鸣禽大脑运动前区域中对歌曲修改至关重要的尖峰信号，并量化了尖峰信号与运动序列中的时间之间的相关性。在给雌鸟唱歌的过程中，孤立的尖峰表示歌声中的时间，而延长的尖峰和沉默的弦线，特别是爆发，则在非直接(独唱)的歌声中编码时间，或称“练习”。在歌曲中的特定时间爆发代码比单个尖峰具有更多的信息，并且这种尖峰-尖峰的协同作用在非定向歌唱中显著更高。观察到的模式信息不能用具有匹配的时变率的泊松模型来解释，这表明对于具有时间代码的歌曲，非定向演唱中的突发峰和定向演唱中的孤立峰的精确定时都是如此。练习中的时间编码支持这样的假设，即nidopallium前神经元的外侧大细胞核在局部情况下及时主动地引导歌曲修改。新的和值得注意的是，这篇论文表明，鸣禽在练习过程中大脑中的脉冲脉冲携带着关于输出运动模式的信息。大脑对歌曲的编码会随着社会环境的变化，在表演和实践中发生变化。在鸟儿的歌声中，尖峰和静音的协同组合代表了时间。这是信息论用于量化有关电机输出的神经信息的首批应用之一。这项活动可能会引导歌曲的变化。
Practice of a complex motor gesture involves motor exploration to attain a better match to target, but little is known about the neural code for such exploration. We examine spiking in a premotor area of the songbird brain critical for song modification and quantify correlations between spiking and time in the motor sequence. While isolated spikes code for time in song during performance of song to a female bird, extended strings of spiking and silence, particularly bursts, code for time in song during undirected (solo) singing, or "practice." Bursts code for particular times in song with more information than individual spikes, and this spike-spike synergy is significantly higher during undirected singing. The observed pattern information cannot be accounted for by a Poisson model with a matched time-varying rate, indicating that the precise timing of spikes in both bursts in undirected singing and isolated spikes in directed singing code for song with a temporal code. Temporal coding during practice supports the hypothesis that lateral magnocellular nucleus of the anterior nidopallium neurons actively guide song modification at local instances in time. NEW & NOTEWORTHY This paper shows that bursts of spikes in the songbird brain during practice carry information about the output motor pattern. The brain's code for song changes with social context, in performance versus practice. Synergistic combinations of spiking and silence code for time in the bird's song. This is one of the first uses of information theory to quantify neural information about a motor output. This activity may guide changes to the song.