Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
复制标题
DOI：
10.1021/om300405h
复制
发表时间：
2012-06
期刊：
影响因子：
2.8
通讯作者：
Yinhua Huang;S. Pullarkat;S. Teong;R. J. Chew;Yongxin Li;P. Leung
中科院分区：
文献类型：
--
作者：
Yinhua Huang;S. Pullarkat;S. Teong;R. J. Chew;Yongxin Li;P. Leung
开发了一种钯环催化的双烯酮与 PhPH2 的非对映和对映选择性逐步双氢膦化反应，允许在一锅中高产率地构建手性三级大 P-杂环。还提出了该反应的催化循环。
A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well.