Cellular mechanotransduction of physical force and organ response to exercise-induced mechanical stimuli
Cellular mechanotransduction of physical force and organ response to exercise-induced mechanical stimuli
复制标题
DOI：
10.7600/jpfsm.4.83
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Hajime Yano;Mohammed E. Choudhury;Afsana Islam;Kana Kobayashi;Junya Tanaka
中科院分区：
文献类型：
--
作者：
Hajime Yano;Mohammed E. Choudhury;Afsana Islam;Kana Kobayashi;Junya Tanaka
运动引起的机械刺激对人体的可变影响正在得到更好的理解。此外，从观察到的肌肉和骨骼退化中可以看出，恒定重力对人体构建和维持生物体的不可或缺的作用是由长期横卧或访问无重力环境（如太空）引起的。基于身体的反应，细胞面对各种输入在很大程度上取决于基因表达，生化过程，或两者兼而有之。因此，很容易想象物理输入可以转化为化学过程。将物理力（机械刺激）转化为细胞中的化学反应的转换过程称为机械转导。越来越多的研究检查力学转导导致了一个新的阶段，在了解运动诱导的生物体的影响。
The variable effects of mechanical stimuli induced by exercise on the human body are becoming better understood. Additionally, the indispensable effect of constant gravity on the human body to construct and maintain living organisms is known from observed muscle and bone regression induced by long-term recumbency or visits to gravity-free environments, such as space. Based on reactions of the body, cells faced with various inputs largely depend on gene expression, biochemical processes, or both. Thus, it is easy to imagine that physical input can be converted into a chemical process. The conversion process that changes physical forces (mechanical stimuli) into chemical reactions in a cell is called mechanotransduction. A growing number of studies examining mechanotransduction have led to a new phase in the understanding of exercise-induced effects on organisms.