Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United states)
Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United states)
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DOI：
10.1007/s10552-005-0416-1
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发表时间：
2006-05-01
影响因子：
2.3
通讯作者：
Egan, KM
中科院分区：
文献类型：
--
作者：
Peterson, NB;Trentham-Dietz, A;Egan, KM
目的：通过绝经状态检查人体测量指标与卵巢癌之间的关系。方法：我们分析了一项基于人群的病例对照研究的数据，该研究包括 1993 年至 2001 年间来自马萨诸塞州和威斯康星州的 700 例上皮性卵巢癌发病病例和 5,943 例对照人群。通过电话采访，收集了有关已确定的卵巢癌危险因素以及成人身高和特定年龄体重的信息。使用 Logistic 回归来估计一生中体重指数 (BMI) 的多变量调整比值比 (OR) 和 95% 置信区间 (CI)。结果：在调整年龄和其他卵巢癌危险因素后，近期 BMI 与卵巢癌风险没有显着相关性（连续 BMI 的 P 趋势为 0.14）。然而，在 20 岁时观察到 BMI 呈非显着正相关（总体 P 趋势 0.08）；将体重 > 25 kg/m2 与最低五分位数进行比较的风险评估（
Objective: To examine the relationship between anthropometric measures and ovarian cancer by menopausal status.Methods: We analyzed data from a population-based case-control study comprised of 700 incident cases of epithelial ovarian cancer and 5,943 population controls from Massachusetts and Wisconsin enrolled between 1993 and 2001. In a telephone interview, information was gathered on established ovarian cancer risk factors, as well as adult height and age-specific body weight. Logistic regression was used to estimate multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for body mass index (BMI) throughout life.Results: Recent BMI had no significant association with ovarian cancer risk (P-trend 0.14 for continuous BMI), after adjustment for age and other ovarian cancer risk factors. However, a non-significant positive association (overall P-trend 0.08) was observed for BMI at age 20; the risk estimate comparing a body mass of > 25 kg/m2 to the lowest quintile (