Relative Wall Thickness and the Risk for Ventricular Tachyarrhythmias in Patients With Left Ventricular Dysfunction
Relative Wall Thickness and the Risk for Ventricular Tachyarrhythmias in Patients With Left Ventricular Dysfunction
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DOI：
10.1016/j.jacc.2015.10.076
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发表时间：
2016-01-26
影响因子：
24
通讯作者：
Barsheshet, Alon
中科院分区：
文献类型：
--
作者：
Biton, Yitschak;Goldenberg, Ilan;Barsheshet, Alon
相对壁厚（RWT）定义为后壁厚度除以左室舒张直径的2倍，是左室几何形状的量度，可能是左室功能障碍患者不良事件的标志。目的：本研究旨在探讨MADIT-CRT（心脏再同步化治疗的多中心自动除颤器植入试验）研究中RWT与室性心动过速（VA）风险之间的关系。方法研究人群包括1260例轻度心力衰竭和左束支传导阻滞患者。结果在多变量模型中，与常用的超声心动图变量相比，RWT是估计VAs风险的最有效的超声心动图测量。低RWT患者(
BACKGROUND Relative wall thickness (RWT), defined as 2 times posterior wall thickness divided by the left ventricular (LV) diastolic diameter, is a measure of LV geometry and may be a marker for adverse events in patients with LV dysfunction.OBJECTIVES The aim of this study was to investigate the relationship between RWT and the risk for ventricular tachyarrhythmia (VA) in patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study.METHODS The study population comprised 1,260 patients with mild heart failure and left bundle branch block.RESULTS In a multivariable model, RWT was the most powerful echocardiographic measure for estimating the risk of VAs compared with commonly used echocardiographic variables. Patients with low RWT (