Familial aggregation of ischemic stroke in young women: The stroke prevention in young women study
Familial aggregation of ischemic stroke in young women: The stroke prevention in young women study
复制标题
DOI：
10.1002/gepi.20171
复制
发表时间：
2006-11-01
影响因子：
2.1
通讯作者：
Kittner, Steven J.
中科院分区：
文献类型：
--
作者：
MacClellan, Leah R.;Mitchell, Braxton D.;Kittner, Steven J.
背景和目的：中风在年轻人中很少发生。虽然老年性卒中的家族基础已经建立，但老年性卒中的家族聚集程度尚不清楚。为了解决这个问题，我们比较了中风病例的亲属中风的频率，在不同年龄和中风subtype.Methods控制的亲属：通过以人群为基础的病例对照研究中风，我们确定了487名妇女年龄在15 - 49岁缺血性中风和615名妇女没有中风的年龄和地理区域相匹配。通过标准化访谈收集了5，749例病例和对照先证者亲属（父母和兄弟姐妹）的卒中家族史。结果：149名病例组和119名对照组的亲属报告了脑卒中。与对照组的兄弟姐妹相比，卒中病例患者的母亲卒中风险超过4倍（OR，4.17; 95%CI，1.9 - 8.8），卒中病例患者的母亲卒中风险是对照组母亲的两倍（OR，2.02; 95%CI，1.4 - 3.0）。先证者中风和中风家族史之间的关联在15 - 24岁的女性中最强（OR，2.5; 95%CI，0.4 - 15.1），并随先证者年龄增加而降低（25 - 34岁女性的OR为1.6; 95% CI为0.8 - 3.3; 35 - 49岁女性的OR为1.5; 95% CI为1.1 - 1.9;趋势P <0.0001）。结论：我们的结论是，早发性中风聚集在家庭和聚集的程度增加，随着先证者年龄的降低。
Background and Purpose: Stroke occurs infrequently in young adults. While a familial basis for older onset stroke is well established, the extent of familial clustering in young-onset stroke is unknown. To address this issue, we compared the frequency of stroke in relatives of stroke cases to that in relatives of controls across different ages and by stroke subtype.Methods: Through a population-based case-control study of stroke, we identified 487 women aged 15-49 years with ischemic stroke and 615 women without stroke matched by age and geographic region. Family history of stroke was collected for 5,749 relatives (parents and siblings) of case and control probands by standardized interview. Results: Strokes were reported in 149 relatives of case patients and 119 relatives of controls. Siblings of stroke case patients had more than four times the risk of stroke compared to siblings of controls (OR, 4.17; 95% CI, 1.9-8.8) and mothers of stroke case patients had twice the risk of stroke compared to mothers of control subjects (OR, 2.02; 95% CI, 1.4-3.0). The association between stroke in probands and family history of stroke was strongest among women aged 15-24 years (OR, 2.5; 95% CI, 0.4-15.1), and diminished with increasing proband age (OR, 1.6; 95% CI, 0.8-3.3 among women 25-34 years and OR, 1.5; 95% CI, 1.1-1.9 among women 35-49 years; P < 0.0001 for trend). Conclusions: We conclude that young-onset stroke aggregates in families and that the magnitude of aggregation increases with decreasing proband age.