Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study
Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study
复制标题
皮质醇与可的松比率和 11-脱氧皮质醇对糖尿病前期和 2 型糖尿病的性别特异性独立和联合影响：来自河南农村队列研究
DOI：
10.1155/2019/4693817
复制
发表时间：
2019-06
影响因子：
4.3
通讯作者：
Mao Zhenxing
中科院分区：
文献类型：
--
作者：
Liu Xue;Jiang Jingjing;Liu Xiaotian;Luo Zhicheng;Wang Yan;Dong Xiaokang;Wei D;an;Huo Wenqian;Yu Songcheng;Li Linlin;Jin Shuna;Wang Chongjian;Mao Zhenxing
目的探讨皮质醇/皮质醇(F/E)和11-脱氧皮质醇在不同性别间对糖尿病前期和2型糖尿病(T2 DM)的独立作用和联合作用。方法采用病例对照研究方法，对河南省农村队列研究的2676名受试者进行研究。用液相色谱-串联质谱仪测定血清皮质醇、皮质醇和11-脱氧皮质醇。采用条件Logistic回归分析来评估激素和预后之间的关系。结果调整多因素后，女性T2 DM与F/E、11-脱氧皮质醇呈负相关(T3vs.T1：OR=0.56，95%CI：0.39~0.80；T3vs.T1：OR=0.44，95%CI：0.27~0.73)。然而，在男性和女性中，只有11-脱氧皮质醇与糖尿病前期呈负相关。与低F/E和11-脱氧皮质醇的组合相比，中等F/E和高11-脱氧皮质醇的组合与男性糖尿病前期显著相关(OR=0.29，95%CI：0.12~0.71)。此外，高F/E和11-脱氧皮质醇的组合与女性患糖尿病前期(OR=0.39，95%CI：0.21~0.73)和T2 DM(OR=0.25，95%CI：0.12~0.52)的风险最低相关。结论血清F/E水平仅在女性与T2 DM呈负相关，而血清11-脱氧皮质醇水平在男性与糖尿病前期呈负相关，在女性与糖尿病前期及T2 DM呈负相关。此外，它们的结合对T2 DM有协同作用。
Objective The aim of the study was to investigate the independent and combined effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus (T2DM) among different genders. Methods A case-control study was performed including 2676 participants from the Henan Rural Cohort Study. Liquid chromatography-tandem mass spectrometry was used to assess serum cortisol, cortisone, and 11-deoxycortisol. Conditional logistic regression was performed to estimate the associations between hormones and outcomes. Results After adjusting for multiple variables, the negative associations of F/E and 11-dexyocortisol with T2DM were observed in females (T3 vs. T1: OR = 0.56, 95% CI: 0.39-0.80 for F/E; T3 vs. T1: OR = 0.44, 95% CI: 0.27-0.73 for 11-dexyocortisol). However, only 11-dexyocortisol showed a negative association with prediabetes both in males and females. Compared with the combination of low F/E and 11-dexyocortisol, the combination of middle F/E and high 11-dexyocortisol was significantly associated with prediabetes (OR = 0.29, 95% CI: 0.12-0.71) in males. Furthermore, the combination of high F/E and 11-dexyocortisol was associated with the lowest odds of prediabetes (OR = 0.39, 95% CI: 0.21-0.73) and T2DM (OR = 0.25, 95% CI: 0.12-0.52) in females. Conclusions Serum F/E level was negatively associated with T2DM only in females whereas serum 11-deoxycortisol level was negatively associated with prediabetes in males and with prediabetes and T2DM in females. Additionally, their combination has a synergistic effect on T2DM.
登录
查看更多内容
影响因子：
--
作者：
Stephen P. Malkoski;R. Dorin
通讯作者：
Stephen P. Malkoski;R. Dorin
影响因子：
3.8
作者：
James Brian Byrd;A. Rothberg;Robert Chomic;C. Burant;R. Brook;R. Auchus
通讯作者：
James Brian Byrd;A. Rothberg;Robert Chomic;C. Burant;R. Brook;R. Auchus
影响因子：
1.6
作者：
López-Suárez A;Bascuñana-Quirell A;Beltrán-Robles M;Elvira-González J;Fernández-Palacín F;Barroso-Casamitjana E;Solino-Ocaña I
通讯作者：
Solino-Ocaña I
DOI：
10.1136/bmj.323.7325.1375/a
发表时间：
2001-12
期刊：
BMJ : British Medical Journal
影响因子：
--
作者：
K. Barraclough
通讯作者：
K. Barraclough
DOI：
10.1017/cbo9781139207249.009
发表时间：
2012
期刊：
--
影响因子：
--
作者：
W. Marsden
通讯作者：
W. Marsden