Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics.
Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics.
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DOI：
10.1007/s11604-020-01017-0
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发表时间：
2021-01
影响因子：
2.1
通讯作者：
Naganawa S
中科院分区：
文献类型：
--
作者：
Taoka T;Naganawa S
胶质淋巴系统假说提出后，越来越多的关于脑内脑脊液和间质液动力学的研究被报道。已知由于胶质淋巴系统的异常而发展的一系列疾病，包括阿尔茨海默病、创伤性脑损伤、中风或其它病症。这些疾病或病症共享胶质淋巴系统功能障碍或与间质流体动力学相关的其他机制的特征。在这篇综述文章中，我们提出了“中枢神经系统（CNS）间质性流体病”作为一个新的概念，包括疾病的病理主要与异常间质性流体动力学。将这些疾病或病症归类为"CNS间质性流体病"将促进对其机制的理解和用于评估疾病的潜在成像方法以及用于疾病治疗或预防的临床方法的开发。换句话说，具有间质液动力学的观点似乎与理解CNS疾病或病症相关，并且有可能开发用于"CNS间质液病"的新的常见治疗方法或药物。
After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer’s disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose “Central Nervous System (CNS) Interstitial Fluidopathy” as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as “CNS interstitial fluidopathies,” will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for “CNS interstitial fluidopathies.”
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