Complement C3 is a risk factor for the development of diabetes -: A population-based cohort study
Complement C3 is a risk factor for the development of diabetes -: A population-based cohort study
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DOI：
10.2337/diabetes.54.2.570
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发表时间：
2005-02-01
期刊：
影响因子：
7.7
通讯作者：
Lindgärde, F
中科院分区：
文献类型：
--
作者：
Engström, G;Hedblad, B;Lindgärde, F
横断面研究报告了补体 C3、胰岛素和葡萄糖的血浆水平之间存在很强的相关性。这项前瞻性研究探讨了 C3、C4 和其他炎症敏感血浆蛋白（ISP；纤维蛋白原、类粘蛋白、α1-抗胰蛋白酶、触珠蛋白和铜蓝蛋白）水平升高是否与糖尿病的发生有关。对 2,815 名年龄在 38-50 岁的非糖尿病健康男性进行了血浆蛋白测量，这些男性在平均随访 6.1 年后接受了重新检查。研究了糖尿病发展（n = 123）与血浆蛋白基线水平的关系。调整年龄、筛查年份和基线血糖后，对于第一、第二、第三和第四四分位数具有 C3 的男性，发生糖尿病的比值比 (95% CI) 分别为 1.00、2.4 (1.15.3)、2.9 (1.4-6.0) 和 5.6 (2.8-10.9)（趋势：P < 0.00001）。在该模型中，纤维蛋白原、触珠蛋白、C4 和升高的 ISP 数量也与未来的糖尿病有关。在进一步调整潜在的混杂因素（包括 BMI、胰岛素和其他炎症标志物）后，只有 C3 与糖尿病的发展显着相关。我们得出的结论是，患糖尿病的风险与补体 C3 的水平有关。
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.15.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.