Number of Named Partners and Number of Partners Newly Diagnosed With HIV Infection Identified by Persons With Acute Versus Established HIV Infection
Number of Named Partners and Number of Partners Newly Diagnosed With HIV Infection Identified by Persons With Acute Versus Established HIV Infection
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DOI：
10.1097/qai.0b013e3181ac12bf
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发表时间：
2009-12-01
影响因子：
3.6
通讯作者：
Leone, Peter
中科院分区：
文献类型：
--
作者：
Moore, Zack S.;McCoy, Sandi;Leone, Peter
背景：在某些人群中，艾滋病毒的急性感染在传播传播中所占的比例不成比例。我们假设，急性HIV感染者(AHI)会比既往HIV感染者(EHI)找到更多的指定伴侣。方法：我们回顾了北卡罗来纳州的监测数据库，以确定2002年11月1日至2007年10月31日期间所有18岁的HIV确诊者。我们使用多变量模型比较了AHI和EHI(基于核酸扩增和血清学检测)确定的指定伴侣的数量，并比较了这些组确定的伴侣中有关HIV检测的信息。结果：在研究期间，确诊为EHI的9044人和AHI的120人。与EHI患者相比，AHI患者每个索引患者命名的伴侣数量是2.5倍[95%可信区间：2.1至3.0]，每个索引患者新诊断为HIV感染的伴侣数量(95%可信区间：1.1至3.5)为1.9倍。讨论：在北卡罗来纳州，AHI患者标识的命名伴侣和新诊断为HIV感染的伴侣比例高于EHI患者。改进对AHI的检测为干预和潜在地减少艾滋病毒的传播提供了关键机会。
Background: Acute infections with HIV account for a disproportionate share of forward transmission in certain populations. We hypothesized that persons with acute HIV infection (AHI) would identify more named partners than those with established HIV infection (EHI).Methods: We reviewed North Carolina surveillance databases to identify all persons aged >= 18 years in whom HIV was diagnosed during November 1, 2002 to October 31, 2007. We compared the number of named partners identified by persons with AHI versus EHI (based on nucleic acid amplification plus serologic testing) using a multivariable model and also compared information regarding HIV testing among partners identified by these groups.Results: EHI was diagnosed in 9044 persons and AHI in 120 persons during the study period. Persons with AHI named 2.5 times more partners per index patient [95% confidence interval: 2.1 to 3.0] and 1.9 times more partners newly diagnosed with HIV infection per index patient (95% confidence interval: 1.1 to 3.5) as did persons with EHI.Discussion: In North Carolina, persons with AHI identified proportionately more named partners and more partners newly diagnosed with HIV infections than persons with EHI. Improved detection of AHI offers critical opportunities to intervene and potentially reduce transmission of HIV.