Retest Reliability of Mesopic and Dark-Adapted Microperimetry in Patients With Intermediate Age-Related Macular Degeneration and Age-Matched Controls.
Retest Reliability of Mesopic and Dark-Adapted Microperimetry in Patients With Intermediate Age-Related Macular Degeneration and Age-Matched Controls.
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DOI：
10.1167/iovs.18-23878
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发表时间：
2018-03-20
影响因子：
4.4
通讯作者：
Finger, Robert P
中科院分区：
文献类型：
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作者：
Welker, Susanne G;Pfau, Maximilian;Finger, Robert P
目的：目的：探讨中度年龄相关性黄斑变性（iAMD）患者中间视力和暗适应眼底视野检查的期内重测信度（67.3 ± 8.2岁;范围，50-85; 78%女性）和24名健康对照（61.3 ± 5.2岁;范围，50-71; 50%女性）。所有患者均接受了重复的中间视觉（消色差刺激，400-800 nm）和暗适应（红色刺激，627 nm）微视野检查，在中央视网膜的14°上使用33个刺激的网格。结果：PWS的重测信度在患者组和对照组中均较好（重复性系数分别为4.4、4.52、3.96和4.56 dB）。结论：改良的马亚装置可以对iAMD患者进行可靠的中间视觉和暗适应微视野检查。我们发现iAMD与降低的中间视觉和暗适应视网膜敏感性相关。
Purpose: To determine the intrasession test-retest reliability of mesopic and dark-adapted fundus-controlled perimetry in patients with intermediate age-related macular degeneration (iAMD).Methods: We conducted a cross-sectional study with 23 iAMD patients (67.3 ± 8.2 years; range, 50-85; 78% female) and 24 healthy controls (61.3 ± 5.2 years; range, 50-71; 50% female) using a modified MAIA microperimeter. All patients underwent duplicate mesopic (achromatic stimuli, 400-800 nm) and dark-adapted (red stimuli, 627 nm) microperimetry, using a grid of 33 stimuli over 14° of the central retina. Main outcome measure was the intrasession test-retest reliability for pointwise sensitivity (PWS).Results: PWS test-retest reliability was good among mesopic and dark-adapted testing in both patients and controls (coefficient of repeatability of 4.4, 4.52, 3.96, and 4.56 dB, respectively). Mean mesopic sensitivity in patients was 2.62 dB lower than in controls (P < 0.01); mean dark-adapted sensitivity was 2.49 dB lower than in controls (P < 0.01).Conclusions: The modified MAIA device allows for reliable mesopic and dark-adapted microperimetry in iAMD patients. We found that iAMD is associated with both reduced mesopic and dark-adapted retinal sensitivity.