Neural recognition molecules and synaptic plasticity
Neural recognition molecules and synaptic plasticity
复制标题
DOI：
10.1016/s0955-0674(97)80115-9
复制
发表时间：
1997-10-01
影响因子：
7.5
通讯作者：
Schachner, M
中科院分区：
文献类型：
--
作者：
Schachner, M
对神经识别分子的近期研究揭示了它们在个体发育过程中的功能与成年期神经可塑性之间的相似性。在体外细胞水平和体内行为水平的观察都表明，识别分子表达的改变可导致突触效能的变化，而突触功能的改变反过来又会引起识别分子表达的变化。这些变化可表现为突触的形态改变以及信号转导机制的调节。
Recent studies of neural recognition molecules have revealed similarities between their functions during ontogenetic development and in neural plasticity in the adult. Observations both at the cellular level in vitro and at the behavioural level in vivo suggest that altered recognition molecule expression can lead to changes in synaptic efficacy, and alterations in synaptic function in turn evoke changes in recognition molecule expression. These changes can manifest themselves as morphological alterations and modulations of the synapse's signal transduction machinery.