Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors
Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors
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DOI：
10.1634/theoncologist.12-5-535
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发表时间：
2007-01-01
期刊：
影响因子：
5.8
通讯作者：
Chen, Herbert
中科院分区：
文献类型：
--
作者：
Kunnimalaiyaan, Muthusamy;Chen, Herbert
越来越多的文献表明，Notch信号转导是一个比最初认为的更复杂的过程。Noch-1作为癌基因或肿瘤抑制基因的相互矛盾的发现表明，它的作用非常特定于细胞环境。在这篇综述中，我们主要关注Notch-1信号在神经内分泌肿瘤(Net)中的肿瘤抑制作用，例如类癌和甲状腺髓样癌。蚊子会分泌各种生物活性荷尔蒙，这些荷尔蒙会导致衰弱症状。手术是治疗NETs患者的唯一可能的治疗方法。Notch-1信号在这些肿瘤中缺失，并且Notch-1的激活显著降低了肿瘤的体外生长。因此，发现在NETs中激活Notch-1通路的化合物(S)可能是治疗NETS患者的一种潜在策略。
A growing body of literature is demonstrating that Notch signaling is a more complex process than originally thought. Contradictory findings of notch-1 acting as an oncogene or a tumor suppressor revealed that its role is very specific to the cellular context. In this review we focus on the tumor suppressor role of Notch-1 signaling in neuroendocrine tumors (NETs) such as carcinoid and medullary thyroid cancers. NETs secrete various bioactive hormones that can cause debilitating symptoms. Surgery is the only potential curative treatment for the patients with NETs. Notch-1 signaling is absent in these tumors and activation of Notch-1 significantly reduces tumor growth in vitro. Therefore, identification of compound(s) that activate the Notch-1 pathway in NETs could be a potential strategy to treat patients with NETs.