Import of proteins into mitochondria.
Import of proteins into mitochondria.
复制标题
将蛋白质导入线粒体。
DOI：
10.1098/rstb.1988.0036
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Schatz,G
中科院分区：
文献类型：
--
作者：
Eilers,M;Verner,K;Hwang,S;Schatz,G
越来越多的证据表明，细胞质合成的蛋白质注定要输入到线粒体内部，必须至少部分地展开，穿透线粒体膜。在翻译后导入过程中，这种展开过程似乎是一个主要的限速步骤。它可以被稳定蛋白质天然构象的配体阻断，并且似乎伴随着线粒体内膜外ATP的切割。
A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across the mitochondrial membranes. During post-translational import, this unfolding process appears to be a major rate-limiting step. It can be blocked by ligands that stabilize the protein’s native conformation and appears to be accompanied by the cleavage of ATP outside the mitochondrial inner membrane.