Transposition of a long member of the L1 major interspersed DNA family into the mouse beta globin gene locus.
Transposition of a long member of the L1 major interspersed DNA family into the mouse beta globin gene locus.
复制标题
将 L1 主要散布 DNA 家族的长成员转座到小鼠 β 珠蛋白基因座中。
DOI：
10.1093/nar/13.14.5071
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发表时间：
1985
影响因子：
14.9
通讯作者：
Edgell,MH
中科院分区：
文献类型：
--
作者：
Burton,FH;Loeb,DD;Chao,SF;Hutchison3rd,CA;Edgell,MH
高度重复的长散布DNA家族L1Md的长成员（对于家蝇中的L1）通过转座整合到位于小鼠的两个成人β珠蛋白基因之间的靶位点。DNA杂交和核苷酸序列分析表明，该靶位点，这是一个单拷贝DNA侧翼的gibin基因的一部分，是中断的L1元件在一个染色体，但在等位基因和祖先染色体是不间断的。两个成人β珠蛋白基因之间区域的其他大的DNA重排也与这些等位基因染色体相关，并且包括单拷贝DNA和简单和复杂重复DNA的插入或缺失。这导致了基因间区域的广泛重组。然而，这一区域两侧的两个基因之间的距离保持保守，这表明珠蛋白基因的间距可能受到保守选择。
A long member of the highly repeated long interspersed DNA family L1Md (for L1 inMusdomesticus) has integrated by transposition into a target site which lies between the two adult beta globin genes of mouse. DNA hybridization and nucleotide sequence analysis show that this target site, which is part of the single copy DNA flanking the giobin genes, is interrupted by the L1 element in one chromosome but is uninterrupted in both allelic and ancestral chromosomes. Other large DNA rearrangements of the region between the two adult beta globin genes are also associated with these allelic chromosomes, and include insertions or deletions of both single copy DNA and simple and complex repetitive DNA. This has caused extensive reorganization of this intergenic region. However, the distance between the two genes flanking this region remains conserved, suggesting that the spacing of the globin genes may be subject to conservative selection.