Statin Therapy Improves Long-term Survival in Non-ischaemic Cardiomyopathy: A Pooled Analysis of 4500 Patients
Statin Therapy Improves Long-term Survival in Non-ischaemic Cardiomyopathy: A Pooled Analysis of 4500 Patients
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DOI：
10.1016/j.hlc.2014.04.007
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发表时间：
2014-10-01
影响因子：
2.6
通讯作者：
Park, Soon J.
中科院分区：
文献类型：
--
作者：
Deo, Salil V.;Rababa'h, Abeer;Park, Soon J.
他汀类药物治疗已证明对慢性心力衰竭患者具有有益作用。虽然大多数缺血性心肌病患者都会服用这些药物，但研究表明，只有不到五分之一的扩张型心肌病患者接受常规他汀类药物治疗。我们对六项研究（四项随机对照试验）中的 4500 名患者进行了荟萃分析。我们的结果表明，他汀类药物治疗显着改善非缺血性心力衰竭患者的长期生存{死亡率风险比0.45（0.33-0.62）； p
Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy.We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p