Stem cells and cellular origins of breast cancer: updates in the rationale, controversies, and therapeutic implications.
Stem cells and cellular origins of breast cancer: updates in the rationale, controversies, and therapeutic implications.
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乳腺癌的干细胞和细胞起源：基本原理、争议和治疗意义的最新进展
DOI：
10.3389/fonc.2019.00820
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发表时间：
2019
影响因子：
4.7
通讯作者：
Yiding Chen
中科院分区：
文献类型：
--
作者：
Jiaojiao Zhou;Qishan Chen;Yiheng Zou;Huihui Chen;Lina Qi;Yiding Chen
乳腺癌干细胞在乳腺癌的发生和临床治疗耐药性中起着重要作用。目前的研究表明，乳腺癌干细胞群体是异质性的，涉及各种细胞标志物和调节信号通路。此外，乳腺癌的不同亚型表现出不同的乳腺癌干细胞亚型和频率。在这篇综述中，我们提供了乳腺癌干细胞的特点，包括其各种分子标记物，突出的调节信号，和复杂的微环境的概述。乳腺癌的细胞起源进行了讨论，以了解干细胞的异质性和多样性分化。重要的是，我们还概述了乳腺癌干细胞在不同亚型乳腺癌中的治疗意义的最新进展和争议。
Breast cancer stem cells have been known to contribute immensely to the carcinogenesis of the breast and therapeutic resistance in the clinic. Current studies show that the population of breast cancer stem cells is heterogeneous, involving various cellular markers and regulatory signaling pathways. In addition, different subtypes of breast cancer exhibit distinct subtypes and frequencies of breast cancer stem cells. In this review, we provide an overview of the characteristics of breast cancer stem cells, including their various molecular markers, prominent regulatory signaling, and complex microenvironment. The cellular origins of breast cancer are discussed to understand the heterogeneity and diverse differentiations of stem cells. Importantly, we also outline the recent advances and controversies in the therapeutic implications of breast cancer stem cells in different subtypes of breast cancer.