Absorption of 8-hydroxyquinolines through the human skin.
Absorption of 8-hydroxyquinolines through the human skin.
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8-羟基喹啉通过人体皮肤吸收。
DOI：
10.2340/0001555558407411
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发表时间：
1978
影响因子：
3.6
通讯作者：
P. Hartvig
中科院分区：
文献类型：
--
作者：
T. Fischer;C. Fagerlund;P. Hartvig
在 14 名患有广泛性皮肤病的患者中研究了软膏或乳膏基质中氯碘羟喹和氯喹那多的皮肤吸收情况。使用氯碘羟喹时血清浓度达到0.3--1.3微克/毫升范围，使用氯喹那多时血清浓度在第二天达到0.05--0.1微克/毫升范围，并在整个局部治疗过程中持续存在。氯碘羟喹和氯喹那多的平均血清半衰期估计分别为25和6小时。治疗结束后局部使用氧化锌软膏，螯合结合氯碘羟喹的皮肤沉积物，并将血清半衰期降低至11小时。氯碘羟喹和氯喹那多的施用量的平均每日尿排泄率分别为4.5%和6%。
The skin absorption of clioquinol and chloroquinaldol in ointment or cream base was studied in fourteen patients with widespread dermatoses. A serum concentration in the range of 0.3--1.3 microgram/ml using clioquinol and 0.05--0.1 microgram/ml with chloroquinaldol was reached by the second day and persisted throughout the topical treatment. The mean serum half-life of clioquinol and of chloroquinaldol was estimated to 25 and 6 hours, respectively. Local application of zinc oxide ointment after the end of the treatment chelate-bound the skin deposits of clioquinol and lowered the serum half-life to 11 hours. The mean daily urinary excretion of the applied amount of clioquinol and chloroquinaldol was 4.5 and 6%, respectively.