Modulation of synaptic plasticity by the coactivation of spatially distinct synaptic inputs in rat hippocampal CA1 apical dendrites
Modulation of synaptic plasticity by the coactivation of spatially distinct synaptic inputs in rat hippocampal CA1 apical dendrites
复制标题
大鼠海马 CA1 顶端树突空间不同突触输入的共激活对突触可塑性的调节
DOI：
10.1016/j.brainres.2013.05.023
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发表时间：
2013
期刊：
影响因子：
2.9
通讯作者：
Takeshi Aihara
中科院分区：
文献类型：
--
作者：
Masashi Kondo;Tatsuo Kitajima;Satoshi Fujii;Minoru Tsukada;Takeshi Aihara
突触前和突触后尖峰之间的相对定时决定了关键时间窗口中突触变化的方向和程度的现象被称为尖峰定时依赖性突触可塑性（STDP）。我们以前曾报道过，STDP档案可以分为两种类型，这取决于他们的层特定的位置沿着CA 1锥体神经元树突在大鼠海马，这表明有不同的信息处理之间的近端树突（PD）和远端树突（DD）。然而，不同类型的信息处理如何在不同的树突位置相互作用仍然不清楚。为了研究PD输入的时间信息如何影响DD的信息处理，PD刺激被施加，同时STDP协议被施加在CA 1锥体神经元的DD。突触可塑性诱导的STDP协议在DDs增强或抑制取决于反向传播动作电位（bAP）和兴奋性和抑制性突触后电位引起的PD刺激的时间。这些结果表明，bAP作为载体的PD输入到DD的时间信息。接下来，使用相同的方案研究DD对PD的影响。突触可塑性在PD调制，只有当配对刺激被施加到引起巧合的时机的bAP和兴奋性突触后电位。这种编码调制可以为一种新的学习规则提供基础，并且可能是大脑神经网络中时空输入信息整合的重要因素。
The phenomenon whereby the relative timing between presynaptic and postsynaptic spiking determines the direction and extent of synaptic changes in a critical temporal window is known as spike timing-dependent synaptic plasticity (STDP). We have previously reported that STDP profiles can be classified into two types depending on their layer-specific location along CA1 pyramidal neuron dendrites in the rat hippocampus, suggesting that there are differences in information processing between the proximal dendrite (PD) and distal dendrite (DD). However, how the different types of information processing interact at different dendritic locations remains unclear. To investigate how the temporal information of inputs to PD influences information processing at DD, PD stimulation was applied while the STDP protocol was simultaneously applied at DDs of CA1 pyramidal neurons. Synaptic plasticity induced by the STDP protocol at DDs was enhanced or depressed depending on the timing of the back-propagating action potentials (bAPs) and the excitatory and inhibitory postsynaptic potentials elicited by PD stimulation. These results suggested that bAPs function as carriers of temporal information of PD inputs to DD. Next, the influence of DD on PD was investigated using the same protocol. Synaptic plasticity at PD was modulated only if the pairing stimuli were applied to elicit coincidental timing of bAP and the excitatory postsynaptic potential. Such coding modulations could provide the basis for a novel learning rule and may be important factors in the integration of spatiotemporal input information in neural networks in the brain.