Effect of motor versus sensory nerve grafts on peripheral nerve regeneration
Effect of motor versus sensory nerve grafts on peripheral nerve regeneration
复制标题
DOI：
10.1016/j.expneurol.2004.08.003
复制
发表时间：
2004-12-01
影响因子：
5.3
通讯作者：
Mackinnon, SE
中科院分区：
文献类型：
--
作者：
Nichols, CM;Brenner, MJ;Mackinnon, SE
自体神经移植是目前治疗神经损伤导致神经间隙的标准方法。这种治疗需要使用感觉移植物来重建运动缺陷，但移植物和天然神经之间不匹配的后果尚不清楚。运动通路已被证明优先支持运动神经元再生。运动神经重建的功能结果取决于终末器官神经再支配的程度、速度和精度。本研究探讨了混合性神经缺损中通路类型对再生的作用。36只刘易斯大鼠行胫神经切断术，并接受同基因运动、感觉或混合神经移植。3周时再生神经的组织形态学显示通过运动神经和混合神经移植物的强大神经再生。而感觉神经移植后神经再生较差，神经纤维数、神经百分比和神经密度均较混合组和移植组明显减少（P < 0.05）。这些数据表明，使用运动或混合神经移植物，而不是感觉神经移植物，将优化混合神经缺损的再生。(C)2004年爱思唯尔公司All rights reserved.
Autologous nerve grafting is the current standard of care for nerve injuries resulting in a nerve gap. This treatment requires the use of sensory grafts to reconstruct motor defects, but the consequences of mismatches between graft and native nerve are unknown. Motor pathways have been shown to preferentially support motoneuron regeneration. Functional outcome of motor nerve reconstruction depends on the magnitude, rate, and precision of end organ reinnervation. This study examined the role of pathway type on regeneration across a mixed nerve defect. Thirty-six Lewis rats underwent tibial nerve transection and received isogeneic motor, sensory or mixed nerve grafts. Histomorphometry of the regenerating nerves at 3 weeks demonstrated robust nerve regeneration through both motor and mixed nerve grafts. In contrast, poor nerve regeneration was seen through sensory nerve grafts, with significantly decreased nerve fiber count, percent nerve, and nerve density when compared with mixed and rnotor groups (P < 0.05). These data suggest that use of motor or mixed nerve grafts, rather than sensory nerve grafts, will optimize regeneration across mixed nerve defects. (C) 2004 Elsevier Inc. All rights reserved.