SQUAMOUS CELL CANCER OF THE HEAD AND NECK WITH DISTANT METASTASIS AT PRESENTATION
SQUAMOUS CELL CANCER OF THE HEAD AND NECK WITH DISTANT METASTASIS AT PRESENTATION
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DOI：
10.1002/hed.21529
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发表时间：
2011-05-01
影响因子：
2.9
通讯作者：
Morgensztern, Daniel
中科院分区：
文献类型：
--
作者：
Kuperman, David I.;Auethavekiat, Vorachart;Morgensztern, Daniel
背景。目前的文献报道头颈鳞状细胞癌（SCCHN）的远处转移率存在很大差异。我们使用监测流行病学和最终结果（SEER）数据库来确定远处转移的发生率和危险因素。方法。我们确定了 1988 年至 2003 年间诊断出的 SCCHN 患者。确定远处转移率，然后根据肿瘤部位、大小和淋巴结状态进行分层。为了评估每个因素的贡献，进行了单变量和多变量分析。结果。在确定的 73,247 名患者中，2066 名患者（2.82%，95% 置信区间 [CI] 2.70-2.94%）出现远处转移。远处转移的独立危险因素包括原发部位、淋巴结状态、肿瘤大小、年龄和种族。结论。在 SCCHN 中，远处转移的风险与肿瘤部位、大小和淋巴结状态之间存在关系。该信息可用于指导 SCCHN 的评估和治疗。 (C) 2010 Wiley periodicals, Inc.* Head Neck 33: 714-718, 2011
Background. Current literature reports widely different rates of distant metastasis at presentation for squamous cell carcinoma of the head and neck (SCCHN). We used the Surveillance Epidemiology and End Results (SEER) database to determine the rate of and risk factors for distant metastasis.Methods. We identified patients with SCCHN diagnosed between 1988 and 2003. The rate of distant metastasis was determined and then stratified by tumor site, size, and nodal status. To evaluate the contribution of each individual factor, both univariate and multivariate analyses were performed.Results. Among 73,247 patients identified, 2066 patients (2.82%, 95% confidence interval [CI] 2.70-2.94%) had distant metastasis. Independent risk factors for distant metastasis included primary site, nodal status, tumor size, age, and race.Conclusions. In SCCHN, there is a relationship between the risk of distant metastasis and tumor site, size, and nodal status. This information can be used to guide the evaluation and treatment of SCCHN. (C) 2010 Wiley Periodicals, Inc.* Head Neck 33: 714-718, 2011