CHRONIC DEAFFERENTATION IN MONKEYS DIFFERENTIALLY AFFECTS NOCICEPTIVE AND NONNOCICEPTIVE PATHWAYS DISTINGUISHED BY SPECIFIC CALCIUM-BINDING PROTEINS AND DOWN-REGULATES GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTORS AT THALAMIC LEVELS
CHRONIC DEAFFERENTATION IN MONKEYS DIFFERENTIALLY AFFECTS NOCICEPTIVE AND NONNOCICEPTIVE PATHWAYS DISTINGUISHED BY SPECIFIC CALCIUM-BINDING PROTEINS AND DOWN-REGULATES GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTORS AT THALAMIC LEVELS
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DOI：
10.1073/pnas.89.7.2571
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发表时间：
1992-04-01
影响因子：
11.1
通讯作者：
JONES, EG
中科院分区：
文献类型：
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作者：
RAUSELL, E;CUSICK, CG;JONES, EG
皮肤和外周组织的慢性传入神经阻滞与大脑皮层中表征地图的可塑性以及包括严重“中枢”疼痛在内的感觉体验的扰动有关。这项研究表明，在正常猴子的非伤害性，丘系组成部分的体感通路在脊髓，脑干和丘脑水平的细胞和纤维的钙结合蛋白parvalbumin免疫反应性的区别，而细胞的伤害性成分在这些水平的区别由28 kDa的calbindin的免疫反应性。猴子的长期背根切断导致脑干和丘脑部位的小清蛋白细胞跨神经元变性，同时伴有丘脑中γ-氨基丁酸A型受体的下调以及优先受神经支配的钙结合蛋白细胞活性的明显增加。中枢疼痛通路。从抑制释放和不平衡的模式，从丘脑到大脑皮层的体感输入可能构成皮层下机制，诱导的代表地图和扰动的感觉知觉，包括中枢疼痛的变化。
Chronic deafferentation of skin and peripheral tissues is associated with plasticity of representational maps in cerebral cortex and with perturbations of sensory experience that include severe "central" pain. This study shows that in normal monkeys the nonnociceptive, lemniscal component of the somatosensory pathways at spinal, brainstem, and thalamic levels is distinguished by cells and fibers immunoreactive for the calcium-binding protein parvalbumin, whereas cells of the nociceptive component at these levels are distinguished by immunoreactivity for 28-kDa calbindin. Long-term dorsal rhizotomies in monkeys lead to transneuronal degeneration of parvalbumin cells at brainstem and thalamic sites accompanied in the thalamus by a down-regulation of gamma-aminobutyric acid type A receptors and an apparent increase in activity of calbindin cells preferentially innervated by central pain pathways. Release from inhibition and imbalance in patterns of somatosensory inputs from thalamus to cerebral cortex may constitute subcortical mechanisms for inducing changes in representational maps and perturbations of sensory perception, including central pain.