Emerging Role of Micro-RNAs in the Regulation of Angiogenesis.
Emerging Role of Micro-RNAs in the Regulation of Angiogenesis.
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DOI：
10.1177/1947601911423032
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发表时间：
2011-12-01
期刊：
影响因子：
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通讯作者：
Cheresh, David A
中科院分区：
文献类型：
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作者：
Anand, Sudarshan;Cheresh, David A
在发育过程中，血管生成是一系列可控的事件，导致新生血管形成，从而支持不断变化的组织需求。几个促血管生成和抗血管生成因子协调了一个复杂的动态过程，允许血管最初的萌芽和入侵，随后的修剪和重塑，最后成熟和存活。在过去的十年中，一类被称为微RNA （miRs）的新型小RNA分子已经成为包括血管生成在内的几种细胞过程的关键调节因子。miR-132、miR-126、miR-296、miR-145和miR-92a等微rna已被证明在内皮细胞和血管周围细胞的血管系统中发挥促血管生成和抗血管生成作用。然而，在癌症或炎症等病理情况下，相同的血管生成信号通路和mir被失调和利用，通常导致血管组织不良，具有泄漏和弯曲的特性。本文简要概述了已报道的在脉管系统中起作用的特定mir。作者探讨了新出现的原理，表明miRs将细胞过程从外部扰动中隔离出来，并在血管生成的背景下为生物系统提供鲁棒性。
During development, angiogenesis occurs as a controlled series of events leading to neovascularization that supports changing tissue requirements. Several pro- and antiangiogenic factors orchestrate a complex, dynamic process to allow initial sprouting and invasion, subsequent pruning and remodeling, and finally maturation and survival of blood vessels. In the last decade, a new class of small RNA molecules termed micro-RNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. Micro-RNAs such as miR-132, miR-126, miR-296, miR-145, and miR-92a have been shown to play pro- and antiangiogenic roles in the vasculature of both endothelial cells and perivascular cells. However, in pathological situations such as cancer or inflammation, the same angiogenic signaling pathways and miRs are dysregulated and exploited, typically resulting in poorly organized vessels with leaky and tortuous properties. This article is a brief overview of specific miRs that have been reported to play a role in the vasculature. The authors explore emerging principles that suggest miRs insulate cellular processes from external perturbations and provide robustness to biological systems in the context of angiogenesis.