Osteoporosis in adult Sri Lankan inflammatory bowel disease patients
Osteoporosis in adult Sri Lankan inflammatory bowel disease patients
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DOI：
10.3748/wjg.15.3528
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发表时间：
2009-07-28
影响因子：
4.3
通讯作者：
de Silva, Hithanadura Janaka
中科院分区：
文献类型：
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作者：
de Silva, Aduna Priyadarsin;Karunanayake, Aranjan Lionel;de Silva, Hithanadura Janaka
目的：确定炎症性肠病（IBD）是否是斯里兰卡成年人骨质疏松症的危险因素。方法：我们从连续就诊于门诊的IBD患者中确定了符合条件的受试者。我们只纳入了年龄在20至70岁之间的患者。在过去6个月内，怀孕、有显著合并症或正在服用钙补充剂或骨质疏松症治疗的患者被排除在外。还招募了年龄和性别匹配的健康对照，对照与患者的比例为3:1。两组均采用外周双能x线吸收仪扫描筛查骨质疏松症。结果：研究人群包括111例IBD患者（男：女= 43:68，平均年龄42.5岁）和333例对照组（男：女= 129:204，平均年龄43.8岁）。IBD患者骨质疏松发生率（13.5%）显著高于对照组（4.5%）（P = 0.001）。溃疡性结肠炎（14.45%）与克罗恩病（10.7%）骨质疏松发生率无显著性差异。然而，在多变量分析中，只有年龄（P = 0.001）、更年期（P = 0.024）和全身性类固醇的使用（P < 0.001）被发现与骨质疏松症的发生独立相关，而IBD、疾病严重程度、复发次数、疾病持续时间或除全身性类固醇以外的治疗与骨质疏松症的发生无关。结论：IBD似乎不是该人群发生骨质疏松症的独立危险因素。然而，全身性类固醇的使用是一个危险因素。(C) 2009 WJG出版社和白石登出版社。版权所有。
AIM: To determine if inflammatory bowel disease (IBD) is a risk factor for osteoporosis in adult Sri Lankans.METHODS: We identified eligible subjects from among consecutive patients diagnosed with IBD who attended our outpatient clinic. We included only patients aged between 20 and 70 years. Patients who were pregnant, had significant comorbidity, or were on calcium supplements or treatment for osteoporosis within the past 6 mo, were excluded. Healthy, age- and sex-matched controls were also recruited, in a control to patient ratio of 3:1. Both groups were screened for osteoporosis using peripheral dual energy X-ray absorptiometry scanning.RESULTS: The study population consisted of 111 IBD patients (male:female = 43:68; mean age 42.5 years) and 333 controls (male:female = 129:204; mean age 43.8 years). The occurrence of osteoporosis among IBD patients (13.5%) was significantly higher than among controls (4.5%) (P = 0.001). The frequency of osteoporosis was not significantly different between ulcerative colitis (14.45%) and Crohn's disease (10.7%). However, on multivariate analysis, only age (P = 0.001), menopause (P = 0.024) and use of systemic steroids (P < 0.001) were found to be associated independently with the occurrence of osteoporosis, while IBD, severity of disease, number of relapses, duration of illness or treatment other than systemic steroids were not.CONCLUSION: IBD does not appear to be an independent risk factor for the occurrence of osteoporosis in this population. However, the use of systemic steroids was a risk factor. (C) 2009 The WJG Press and Baishideng. All rights reserved.