Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
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DOI：
10.1038/sj.jid.5701213
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发表时间：
2008-05-01
影响因子：
6.5
通讯作者：
Krueger, James G.
中科院分区：
文献类型：
--
作者：
Lowes, Michelle A.;Kikuchi, Toyoko;Krueger, James G.
T辅助17(Th17)细胞在炎症和自身免疫中的重要性现在正受到重视。我们分析了银屑病皮损和外周血中是否存在产生IL-17的T细胞。我们将Th17细胞主要定位于银屑病皮损的真皮，证实了IL-17mRNA随着疾病活动的增加而增加，并证明了环孢素治疗后IL-17mRNA的表达正常化。IL-22mRNA的表达反映了IL-17的表达，两者都与角蛋白16平行下调。Th17细胞是一个独立的群体，与Th1细胞(银屑病皮损中也存在)和Th2细胞是分开的。我们的发现提示银屑病是一个混合的Th1和Th17炎症环境。Th17细胞可能是银屑病皮肤炎症的近端调节细胞，值得进一步关注作为治疗靶点。
The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.