Antigens in Streptococcus mutans Cross Reactive with Human Heart Muscle
Antigens in Streptococcus mutans Cross Reactive with Human Heart Muscle
复制标题
变形链球菌中的抗原与人类心肌发生交叉反应
DOI：
--
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
J. Zabriskie
中科院分区：
文献类型：
--
作者：
I. V. D. Rijn;A. Bleiweis;J. Zabriskie
一种与哺乳动物心脏组织发生交叉反应的抗原已被证明存在于几种变异S菌株中。将S突变体接种到家兔体内，作为免疫反应的一部分，可引起心脏反应性抗体。这种心脏反应性抗体被证明是组织特异性的，因为它只结合心脏和平滑肌组织。以前使用A群链球菌也报道过类似的结果。利用肌层鞘、A组链球菌膜和龋齿链球菌的部分进行吸附研究，证实了类似抗原的存在。上述组分均能去除免疫兔血清和急性风湿热患者血清中的心脏反应性抗体。这些发现表明，未来有必要对任何含有S突变体部分的龋齿疫苗进行检测，以检测这种交叉反应性抗原的存在，以避免可能的自身免疫。
An antigen that cross reacts with mammalian heart tissue has been shown to be present in several strains of S mutans. Inoculation of S mutans into rabbits elicited heart-reactive antibody as part of the immunologic response. This heart-reactive antibody was demonstrated to be tissue-specific in that it only bound heart and smooth muscle tissue. Similar results have been previously reported using group A streptococci. Adsorption studies using sarcolemmal sheaths, group A streptoccal membranes, and fractions of cariogenic streptococci demonstrated the presence of a similar antigen. The aforementioned fractions could remove heart-reactive antibody from both immune rabbit serums and serums from patients with acute rheumatic fever. These findings dictate the necessity for testing any future caries vaccine containing fractions of S mutans for the presence of this cross-reactive antigen to avoid a possible autoimmunization.