Generating neuronal diversity in the mammalian cerebral cortex.
Generating neuronal diversity in the mammalian cerebral cortex.
复制标题
DOI：
10.1146/annurev-cellbio-100814-125353
复制
发表时间：
2015
影响因子：
11.3
通讯作者：
Arlotta P
中科院分区：
文献类型：
--
作者：
Lodato S;Arlotta P
新皮层是大脑的一部分，负责执行高级大脑功能，包括认知，感官知觉和复杂的运动控制。在进化过程中，新皮层已经发展出无与伦比的神经元多样性，在功能水平上仍然部分未分类和未映射。在这里，我们首先广泛地回顾了新皮层的结构蓝图，并讨论了其神经元多样性的当前分类。然后，我们涵盖的原则和机制，建立在皮层发育神经元的多样性，并考虑在塑造皮层连接和功能的神经元类特异性的身份的影响。
The neocortex is the part of the brain responsible for the execution of higher-order brain functions, including cognition, sensory perception and sophisticated motor control. During evolution, the neocortex has developed an unparalleled neuronal diversity, which still remains partly unclassified and unmapped at the functional level. Here, we first broadly review the structural blueprint of the neocortex and discuss the current classification of its neuronal diversity. We then cover the principles and mechanisms that build neuronal diversity during cortical development and consider the impact of neuronal class-specific identity in shaping cortical connectivity and function.