Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri:: The first natural nitrate esters
Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri:: The first natural nitrate esters
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DOI：
10.1021/jo991740x
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发表时间：
2000-07-28
影响因子：
3.6
通讯作者：
Seldes, AM
中科院分区：
文献类型：
--
作者：
Palermo, JA;Brasco, MFR;Seldes, AM
从采自南格鲁吉亚群岛附近200 m深处的软珊瑚Alcyoniumpaessleri中分离得到15个伊鲁达烷型倍半萜类化合物，即alcyopterosinA-O（1 - 15）。这些化合物中的八种（2、3、5 - 8、10和13）是第一种天然硝酸酯，而其他四种（1、4、11和12）是氯化的。这些化合物也是第一个从海洋环境中分离出来的伊鲁达烷倍半萜类化合物。化合物1、3、5和8对人肿瘤细胞株显示出轻微的细胞毒性。
Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2, 3, 5-8, 10, and 13) are the first natural nitrate esters, while the other four (1, 4, 11, and 12) are chlorinated. These compounds are as well the first illudalane sesquiterpenoids to be isolated from the marine environment. Compounds 1, 3, 5, and 8 showed mild cytotoxicity toward human tumor cell lines.