Polysaccharides from the Fleshy Fruits ofCamellia oleiferaAttenuate the Kidney Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Mice
Polysaccharides from the Fleshy Fruits ofCamellia oleiferaAttenuate the Kidney Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Mice
复制标题
油茶肉质果实中的多糖可减轻高脂饮食/链脲佐菌素诱导的糖尿病小鼠的肾脏损伤。
DOI：
10.1089/jmf.2020.4717
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发表时间：
2020-10-22
影响因子：
2.4
通讯作者：
Wu, Suzhen
中科院分区：
文献类型：
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作者：
Li, Jialin;Xie, Fuhua;Wu, Suzhen
油茶的肉质果实是油茶的未成熟果实。油茶植株受外担病菌侵染后，植株膨大、空心化。它们含有丰富的微量元素和维生素C，在中国农村直接作为野果食用。最近的研究表明C.油茶具有抗炎和抗氧化作用。目前的研究，首次评估了从肉质果实的多糖的肾脏保护能力。链脲佐菌素诱导的糖尿病小鼠饲喂高脂饮食。给糖尿病小鼠灌胃CFFP 3个月，观察CFFP对糖尿病小鼠肾脏的保护作用。结果表明，250 mg/kg CFFP通过降低血清肌酸、血尿素氮水平、肾重/体重比、纤维连接蛋白和胶原表达以及肿瘤坏死因子-α和白细胞介素-6的分泌，显著减轻糖尿病肾损伤。250 mg/kg CFFP可通过升高谷胱甘肽水平和降低丙二醛含量，显著改善肾脏氧化应激。我们证实，CFFP可以发挥抗氧化，抗炎，抗纤维化的活动。CFFP可能是一种潜在的治疗药物，C.油茶可能是未来糖尿病患者的饮食疗法。
The fleshy fruits of Camellia oleifera Abel are the immature fruits of C. oleifera, which are infected by Exobasidium vexans Massee and then turn to be intumescent and hollowed. They contain rich trace elements and vitamin C and are eaten directly as wild fruits in the Chinese countryside. Recent studies report that C. oleifera has anti-inflammatory and antioxidative effects. The current study, for the first time, evaluates the renal protective capacity of polysaccharides from the fleshy fruits of C. oleifera (CFFP) in streptozotocin-induced diabetic mice fed high-fat diets. The diabetic mice were orally administered CFFP for 3 months to evaluate the renoprotective function of CFFP. Our results indicated that 250 mg/kg CFFP significantly alleviated diabetes-induced renal injury by decreasing serum creatine, blood urea nitrogen levels, the kidney/body weight ratio, expression of fibronectin and collagen, as well as the secretion of tumor necrosis factor-α and interleukin-6. Additionally, 250 mg/kg CFFP could significantly ameliorate renal oxidative stress through increasing glutathione levels and lowering malondialdehyde contents. We confirmed that CFFP could exert antioxidative, anti-inflammatory, and antifibrosis activities. CFFP might be a potential therapeutic agent, and the fleshy fruits of C. oleifera might be a diet therapy for diabetic patients in the future.