Ether and crown ether-containing cationic 99mTc complexes useful as radiopharmaceuticals for heart imaging
Ether and crown ether-containing cationic 99mTc complexes useful as radiopharmaceuticals for heart imaging
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DOI：
10.1039/b618406e
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Liu, Shuang
中科院分区：
文献类型：
--
作者：
Liu, Shuang
虽然过去十年放射性药物研究一直集中在开发用于癌症早期检测和放射治疗的目标特异性放射性示踪剂，但在用于心脏成像的新型阳离子 Tc-99m 放射性示踪剂方面的努力有限。本综述将总结含醚和冠醚的阳离子 Tc-99m 放射性示踪剂的一些最新进展，这些示踪剂具有快速肝脏清除率，其心/肝比明显优于目前可用于心肌灌注成像的两种商业 Tc-99m 放射性药物 Tc-99m-Sestamibi 和 Tc-99m-Tetrofosmin。快速肝脏清除可能会缩短成像方案的持续时间（注射后 < 30 分钟），并允许尽早获取高质量的心脏图像。心/肝比率的改善可以更好地检测冠状动脉疾病的存在和程度。鉴定出这样一种新的放射性示踪剂，可以改善心肌灌注的非侵入性描绘，对于治疗疑似冠状动脉疾病的患者将具有相当大的益处。
While radiopharmaceutical research has been focused on the development of target-specific radiotracers for early detection and radiotherapy of cancers in the last decade, there is a limited effort on new cationic Tc-99m radiotracers for heart imaging. This review will summarize some of the most recent developments in ether- and crown ether- containing cationic Tc-99m radiotracers that have a fast liver clearance with a heart/liver ratio substantially better than that of Tc-99m-Sestamibi and Tc-99m-Tetrofosmin, the two commercial Tc-99m radiopharmaceuticals currently available for myocardial perfusion imaging. Fast liver clearance might shorten the duration of imaging protocols (< 30 min post-injection), and allow for early acquisition of heart images of high quality. Improvement of heart/liver ratio may permit better detection of the presence and extent of coronary artery disease. Identification of such a new radiotracer that allows for the improved non-invasive delineation of myocardial perfusion would be of considerable benefit in treatment of patients with suspected coronary artery disease.