Tumor budding is an independent risk factor for lymph node metastasis in cutaneous squamous cell carcinoma: a single center retrospective study.
Tumor budding is an independent risk factor for lymph node metastasis in cutaneous squamous cell carcinoma: a single center retrospective study.
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肿瘤出芽是皮肤鳞状细胞癌淋巴结转移的独立危险因素：单中心回顾性研究。
DOI：
10.1111/cup.12740
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Murata SI.
中科院分区：
文献类型：
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作者：
Fujimoto M;Yamamoto Y;Matsuzaki I;Warigaya K;Iwahashi Y;Kojima F;Furukawa F;Murata SI.
背景虽然肿瘤出芽被认为是某些类型肿瘤淋巴结转移的危险因素，但在皮肤鳞状细胞癌（SCC）中的研究还不多。在这项研究中，我们分析了肿瘤出芽和淋巴结转移之间的相关性在皮肤SCC. MethodsHistological标本15转移和144非转移皮肤SCC进行了回顾性分析。肿瘤出芽的临界点确定在5个或更多个病灶的一个孤立的癌细胞或集群，包括<5个细胞/1.23 mm 2的侵袭性前面的肿瘤下苏木精和伊红section.ResultsTumor budding是阳性的93.3%的转移性皮肤鳞状细胞癌和25.7%的非转移性皮肤鳞状细胞癌，分别（p < 0.0001）。在多变量分析中，在其他风险因素（肿瘤大小、肿瘤厚度、Clark水平和低分化）中，肿瘤出芽是淋巴结转移的独立风险因素（p = 0.0021）。结合肿瘤厚度>4 mm，肿瘤出芽成为预测淋巴结转移的较好指标（敏感性93.3%，特异性84.7%.ConclusionsIn our cohort，tumor budding is a independent risk factor for nodal metastasis.我们的数据表明肿瘤出芽在皮肤SCC风险评估中具有重要作用。
BackgroundAlthough tumor budding is acknowledged as a risk factor for lymph node metastasis in certain types of carcinoma, it is not well investigated in cutaneous squamous cell carcinomas (SCCs). In this study, we analyzed the correlation between tumor budding and nodal metastasis in cutaneous SCC.MethodsHistopathologic specimens of 15 metastasizing and 144 non‐metastasizing cutaneous SCC were retrospectively reviewed. Cut‐off point for tumor budding was determined at five or more foci of an isolated cancer cell or a cluster comprising <5 cells /1.23 mm2in the invasive front of the tumor under hematoxylin and eosin sections.ResultsTumor budding was positive in 93.3% of metastasizing cutaneous SCC and 25.7% of non‐metastasizing cutaneous SCC, respectively (p < 0.0001). In multivariate analysis, tumor budding was an independent risk factor for nodal metastasis among the other risk factors (tumor size, tumor thickness, Clark level and poor differentiation) (p = 0.0021). In combination with tumor thickness >4 mm, tumor budding became a better marker for predicting nodal metastasis (sensitivity 93.3%, specificity 84.7%).ConclusionsIn our cohort, tumor budding was an independent risk factor for nodal metastasis. Our data suggests the promising role of tumor budding in risk evaluation of cutaneous SCC.