Near-infrared optical topography to assess activation of the parietal cortex during a visuo-spatial task
Near-infrared optical topography to assess activation of the parietal cortex during a visuo-spatial task
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DOI：
10.1016/j.neuropsychologia.2005.02.011
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Fallgatter, AJ
中科院分区：
文献类型：
--
作者：
Herrmann, MJ;Ehlis, AC;Fallgatter, AJ
多通道近红外光谱 (NIRS) 是一种基于氧合血红蛋白 (O(2)Hb) 和脱氧血红蛋白 (HHb) 变化来研究大脑激活的相对较新的方法。最近，研究表明，由于认知需求，NIRS 似乎能够检测到 O(2)Hb 和 HHb 浓度的微小变化。本研究旨在调查空间任务期间顶叶皮层 O(2)Hb 和 HHb 浓度的变化，该任务是 Benton Line Orientation Task 的修改版本（Gur, R. C., Alsop, D., Glahn, D., Petty, R., Swanson, C. L., Maldjian, J. A., et al. (2000)。一项关于语言区域激活中性别差异的功能磁共振成像研究 和空间任务。脑与语言，74(2), 157-170.]。 24 名受试者接受了 NIRS 测量，同时他们必须估计给定线的方向或在控制条件下命名线的颜色。两种条件均由三个激活阶段组成，每个激活阶段持续 30 秒，基线为 10 秒，休息后为 20 秒。为了评估 O(2)Hb 和 HHb 浓度的变化，我们测量了 使用 NIBS 设备 ETG-100（日立医疗有限公司）在顶叶皮层上设置 24 个 NIRS 通道。与两种条件的基线相比，O(2)Hb 浓度在活动阶段显着增加，但与双侧顶枕颜色命名条件相比，线定向条件的活动阶段显着较高。对于 HHb 浓度，我们只发现两种情况下均显着降低，但 条件之间没有差异。我们的研究结果强调了多通道 NIRS 在评估认知任务期间皮质激活的价值。 (c) 2005 Elsevier Ltd. 保留所有权利。
Multi-channel near-infrared spectroscopy (NIRS) is a relatively new method to investigate the brain activation, based on changes in oxygenated haemoglobin (O(2)Hb) and deoxygenated haemoglobin (HHb). Recently, it has been shown that NIRS seems to be able to detect even small changes in O(2)Hb and HHb concentration due to cognitive demands. This study aimed at investigating the changes in O(2)Hb and HHb concentrations of the parietal cortex during a spatial task, a modified version of the Benton Line Orientation Task (Gur, R. C., Alsop, D., Glahn, D., Petty, R., Swanson, C. L., Maldjian, J. A., et al. (2000). An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain & Language, 74(2), 157-170.]. Twenty-four subjects were measured with NIRS while they had to estimate the orientation of a given line or to name the colour of the line in the control condition. Both conditions consisted of three activation phases each lasting 30 s, with a 10 s baseline and a 20 s post resting period. For assessing the changes in O(2)Hb and HHb concentrations, we measured with 24 NIRS channels over the parietal cortex using the NIBS apparatus ETG-100 (Hitachi Medical Ltd.). O(2)Hb concentration significantly increased during the active phase compared to the baseline for both conditions, but was significantly higher in the active phase for the line orientation condition compared to the colour naming condition bilaterally parieto-occipital. For the HHb concentrations, we only found significant decreases for both conditions but no differences between the conditions. The results of our study underscore the value of multi-channel NIRS for assessing cortical activation during cognitive tasks. (c) 2005 Elsevier Ltd. All rights reserved.