Continuous flow dynamic nuclear polarization of water under ambient conditions for in-vivo perfusion MRI
Continuous flow dynamic nuclear polarization of water under ambient conditions for in-vivo perfusion MRI
复制标题
环境条件下水的连续流动态核极化用于体内灌注 MRI
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
S. Han
中科院分区：
文献类型：
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作者：
M. Lingwood;S. Tokuyama;E. Brown;S. Han
我们正在开发通过奥弗豪瑟效应使用动态核极化 (DNP)，通过在环境条件下连续生成 DNP 增强水来提高磁共振成像 (MRI) 的对比度。虽然 MRI 是一种强大且常用的体内研究技术，但众所周知，它固有地缺乏灵敏度和对比度。许多应用都需要可视化水的流动或传输，例如大脑的灌注成像，但将感兴趣的水与大量信号分离是很困难的。顺磁剂通常用于增强对比度，但由于它们的尺寸较大，因此不能准确反映系统中水的功能和运输。此外，造影剂可能具有不利的生理作用。
We are developing the use of dynamic nuclear polarization (DNP) via the Overhauser effect to improve contrast for magnetic resonance imaging (MRI), by continuously generating DNP-enhanced water under ambient conditions. While MRI is a powerful and common technique for in-vivo studies, it suffers from a well-known, inherent lack of sensitivity and contrast. Many applications exist where it is desired to visualize the flow or transport of water, such as perfusion imaging of the brain, but separating the water of interest from the bulk signal is difficult. Paramagnetic agents are commonly used to enhance contrast, but these agents do not accurately reflect the function and transport of water in the system due to their large size. In addition, contrast agents can have adverse physiological effects.